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Autoimmune diseases occur in 3–5% of the population as a result of myriad of genetic and environmental factors that lead to altered immune reactivity. The alterations in the immune system initiated by a loss of immunological tolerance to self-antigens lead to the development of autoreactive phenomena that can be detected in the peripheral blood. The present study was undertaken to detect the Extractable Nuclear Antibodies present in the study population. This study was conducted for a period of 1 year in 100 patients attending Rheumatology department. 50 patients had signs and symptoms related to connective tissue disorders and were ANA positive. Another 50 patients had no signs and symptoms related to CTD and were ANA negative. | Screening of extractable nuclear antibodies by ELISA in patients with connective tissue disorders in a Tertiary Care Hospital