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To determine the most common organisms causing surgical site infections and their antibiotic sensitivity pattern. This study was carried out retrospectively in the Department of Microbiology SKIMS Medical College and associated hospital, Srinagar for a period of two years (January 2017–December 2018). A total number of 194 pus samples of inpatients from different wards as well as of out-patients were processed using standard microbiological techniques. Of the 194 pus samples processed, 94 samples were culture positive (48.4%). Escherichia coli was the most commonly isolated organism (36%) followed by Staphylococcus spp. (34%), Klebsiella spp. (11.7%), Acinetobacter spp. (5.3%), Enterococcus spp. (4.25%), Coagulase negative Staphylococci (CONS) (3.1%), Citrobacter spp. (2.12%), Pseudomonas spp. (2.1%) and Proteus spp. (1.06%). All isolates of Escherichia coli were sensitive to Polymyxin-B and 90% sensitive to Imipenem. 14 E.coli isolates (41.17%) were multi-drug resistant. 100% of Staphylococcus and Enterococcus spp. were sensitive to Linezolid, Vancomycin and Teicoplanin. 15(46.87%) isolates of Staphylococcus aureus were Methicillin-resistant Staphylococcus aureus. Surgical site infections are an important cause of morbidity, mortality and economic burden among health care associated infections (HCAI). Absence of data, under-reporting and little or no surveillance of these infections are major areas of concern. | Aerobic bacteriological profile and antibiogram of surgical site infections in a Tertiary care hospital in Kashmir