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Beta cyfluthrin is widely used multipurpose synthetic pyrethroid. Indiscriminate uses resulting to deleterious effects in animal metabolism. Present study has been designed to investigate the effects of beta cyfluthrin on haemato-biochemical alteration in both the sexes of Wistar rats (Rattus norvegicus). Beta cyfluthrin was orally administered, 38.0 mg/kg b. wt. (high dose), 12.66 mg/kg b. wt. (mid dose), 4.22 mg/kg b. wt. (low dose) for 90 days with high dose recovery. Beta cyfluthrin caused marked reduction in Hb concentration, RBCs count, haematocrit, MCH, platelets, lymphocytes whereas an increased in TLC and neutrophil count at different intervals in both the sexes. Serum activities of AST, ALT, ALP, LDH and concentration of total proteins, globulin, creatinine, blood urea nitrogen, glucose, total bilirubin, total cholesterol, triglyceride and total lipids was increased whereas albumin, A:G ratio, sodium and chlorides were significantly decreased. Results showed that liver and kidneys were affected due to toxicity of beta cyfluthrin. Recovery period brought all these parameters within normal range but lipid profile which remained at higher level even after withdrawal of treatment. Thus, beta cyfluthrin should be used with cautiously under areas before untargeted animals. | Haemato-biochemical study: Induced Beta cyfluthrin repeated toxicity with reversal on Wistar rats
