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Candida species is the only fungal pathogen that causes variety of afflictions that ranges from superficial mucosal infections to life-threatening disseminated mycoses. Oral candidiasis is a common fungal infection caused by an overgrowth or infection due to Candida spp. Candida albicans is considered as the primary etiology of various clinical types of candidiasis including oral lesions. However, in recent years research studies have highlighted the greater recognition of non-albicans Candida (NAC) spp. The present study was conducted with an aim to study species distribution and antifungal susceptibility profile of Candida isolates obtained from oral lesions. HIV infection, diabetes, dentures and malignancy were main predisposing factors. C. albicans (79.8%) was the predominant isolate. NAC spp. were isolated from 21(20.2%) cases. Fluconazole resistance was observed in 9.6% of C. albicans whereas 23.8% of NAC spp demonstrated resistance to fluconazole. From this study, it can be concluded that, although an epidemiological shift towards non albicans Candida species is noted in recent years, C. albicans still remains the pervasive pathogen. Antifungal susceptibility testing of Candida isolates is extremely important for selection of most appropriate therapeutic agent. | Species identification and antifungal susceptibility profile of Candida isolates obtained from oral lesions in patients attending outpatient department of academic dental hospital
