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MicroRNAs, a class of short endogenous RNAs, acting as post-transcriptional regulators of gene expression, mostly silence gene expression via binding imperfectly matched sequences in the 3'UTR of target mRNA. MiR-17-92, a highly conserved gene cluster, has 6 members including miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a. | Int. J. Med. Sci. 2018 Vol. 15 1443 IVYSPRING ĩvt ơ-rnrt irmrtí clrni t n lí ei-fCMo Tir lT Qriữvtrơc INTERNATIONAL PUBLISHER international journal Oj jVLeaicaiSciences 2018 15 13 1443-1448. doi 10.7150 ijms.27341 Review Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer Xinju Zhang Yanli Li Pengfei Qi Zhongliang MaE Lab for Noncoding RNA Cancer School of Life Sciences Shanghai University Shanghai 200444 El Corresponding author zlma@shu.edu.cn Tel 86-21-66137015 Fax 86-21-66132177 Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution CC BY-NC license https creativecommons.org licenses by-nc 4.0 . See http ivyspring.com terms for full terms and conditions. Received 2018.05.18 Accepted 2018.07.29 Published 2018.09.07 Abstract MicroRNAs a class of short endogenous RNAs acting as post-transcriptional regulators of gene expression mostly silence gene expression via binding imperfectly matched sequences in the 3 UTR of target mRNA. MiR-17-92 a highly conserved gene cluster has 6 members including miR-17 miR-18a miR-19a miR-20a miR-19b-1 and miR-92a. The miR-17-92 cluster regarded as oncogene is overexpressed in human cancers. Lung cancer is the leading cause of death all over the world. The molecular mechanism of lung cancer has been partly known at the levels of genes and proteins in last decade. However new prognosis biomarkers and more target drugs should be developed in future. Therefore noncoding RNAs especially miRNAs make them as new potentially clinical biomarkers for diagnosis and prognosis. In this review we focus the current progress of miR-17-92 cluster in lung cancer. Key words microRNAs miR-17-92 cluster oncogene lung cancer tumorigenesis Introduction MicroRNAs miRNAs highly conserved small non-coding RNAs cause degradation of target mRNAs or inhibition of translation by binding with 3 -untranslated regions 3 -UTR thus regulate the expression of genes at the .
