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Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics

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A disintegrin and metalloprotease (ADAM) family proteins are type-I transmembrane glycoproteins with multiple functions in cell adhesion, migration, proteolysis and signaling. ADAM10 is a member of the ADAM family reportedly involved in cancer progression and has been shown to be overexpressed in hepatocellular carcinoma (HCC) tissues and significantly associated with tumor progression and shortened survival. | Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics

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