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In this paper we review some of the novel aspects of cannabis and cannabinoids in relation to their legal situation, changes in their composition and forms of cannabis use, the concept of medical cannabis, and synthetic cannabinoids as new psychoactive substances (NPS). | Int. J. Med. Sci. 2018 Vol. 15 1286 IVYSPRING ĩvt ơ-rnrt irmrtí clrni t n lí ei-fCMo Tir lT Qriữvtrơc INTERNATIONAL PUBLISHER international journal Oj jVLeaicaiSciences 2018 15 12 1286-1295. doi 10.7150 ijms.27087 Review Cannabinoids from pot to lab Esther Papaseit1 2 Clara Perez-Mana1 2 Ana Pilar Perez-Acevedo1 2 Olga Hladun1 2 M. Carmen Torres-Moreno1 2 Robert Muga2 3 Marta Torrens2 4 Magi Farre1 2 1. Clinical Pharmacology Unit Hospital Universitari Germans Trias i Pujol HUGTP-IGTP Badalona Spain . 2. Universitat Autònoma de Barcelona UAB Cerdanyola del Vallès Barcelona Spain . 3. Internal Medicine Department Universitari Germans Trias i Pujol HUGTP-IGTP Badalona Spain . 4. Drug Addiction Program Institut de Neuropsiquiatria i Adiccions INAD Parc de Salut Mar Barcelona Spain . Corresponding author Magi Farre. Clinical Pharmacology Unit Hospital Universitari Germans Trias i Pujol Carretera de Canyet s n. 08916 Badalona. Spain. Phone. 34 93 4978865 34 93 4651200 email mfarre.germanstrias@gencat.cat. Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution CC BY-NC license https creativecommons.org licenses by-nc 4.0 . See http ivyspring.com terms for full terms and conditions. Received 2018.05.05 Accepted 2018.06.30 Published 2018.08.06 Abstract Cannabis is becoming increasingly present in our society. In recent years the line between the natural cannabis and the synthetic synthetic cannabinoids the recreational cannabis and the medical pharmaceutical cannabinoids and medical cannabis has been crossed. In this paper we review some of the novel aspects of cannabis and cannabinoids in relation to their legal situation changes in their composition and forms of cannabis use the concept of medical cannabis and synthetic cannabinoids as new psychoactive substances NPS . We have also analyzed serious adverse reactions and intoxications associated with the use of synthetic cannabinoids as well as the