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To determine the prevalence of depression disturbances and factors related to depression of 457 high school students in Danang City. Methods: Cross-sectional study and using DASS 42 scale. Results: The incidence of depression among high school students in Danang was 40.9%, including mild, moderate, severe and very severe levels (14.0%, 13.1% and 13.8%, respectively). Friends and living conditions, family conflicts, isolation of friends, study pressures, self-targeting, feelings of inferior to friends and using alcohol are all related to depression (p | The current depression situation of public high school students in Danang city