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Objectives: To evaluate the change of analgesia/nociception index values and average dose of sufentanil in surgery and to find out the relationship between analgesia/nociception index values and VAS score post-operation and its side effects. Subjects and methods: 60 patients, ASA I, II, aged 15 to 60 years undergoing digestive surgery were enrolled in the study. | Journal of military pharmaco-medicine no1-2019 EVALUATION OF THE VARIABILITY OF ANALGESIA/ NOCICEPTION INDEX VALUES IN DIGESTIVE SURGERY Luu Quang Thuy1; Trinh Ke Diep1; Nguyen Quoc Kinh1 SUMMARY Objectives: To evaluate the change of analgesia/nociception index values and average dose of sufentanil in surgery and to find out the relationship between analgesia/nociception index values and VAS score post-operation and its side effects. Subjects and methods: 60 patients, ASA I, II, aged 15 to 60 years undergoing digestive surgery were enrolled in the study. Participants were randomly divided into 2 groups. A standardized anesthetic regimen (sevoflurane, BIS monitoring, epidural analgesia maintenance with levobupivacaine 0.1% 5 mL/h, analgesia/nociception index monitoring) was utilized for both groups. Group 1 was received sufentanil under the guidance of analgesia/nociception index monitor (0.2 mcg/kg when analgesia/nociception index value < 50). Group 2 was received sufentanil 0.2 mcg/kg every hour. Results and conclusions: Analgesia/ nociception index values in the group 1 (58.7 ± 16.39) was 1.5 times lower than the group 2 (77.4 ± 12.29) with p < 0.001. Average dose of sufentanil in the analgesia/nociception index group patients (the group 1) (20.89 ± 5.75 µg) was statistically significant lower than the standard group patients (the group 2) (38.02 ± 15.55 µg). A good negative linear relationship 2 between analgesia/nociception index score and VAS with r = -0,605 (r = 0.366) was recorded. A reduced incidence of vomiting, nausea (analgesia/nociception index: 16.7% and standard: 33.3%) and slow breathing (analgesia/nociception index : 3.3% and standard: 13.3%) was observed. * Keywords: Digestive surgery; Analgesia/nociception index value. INTRODUCTION Digestive surgery is one of the most painful dissection. Acknowledging and evaluating the level of pain in peri-operation and post-operation is of great necessity. This helps us give accurately analgesics and avoid .
