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Objectives: To evaluate the treatment result of clozapine in schizophrenic patients respond poorly to classic neuroleptiques. Subjects and methods: A prospective, cross-sectional, caseby-case analysis on 61 schizophrenic inpatients who responded poorly to classic haloperidol, aged 16 to 55 years and received treatment at National Psychiatric Hospital No 1 between 2014 and 2017. | Journal of military pharmaco-medicine no7-2018 THE ASSOCIATION BETWEEN DOSE OF CLOZAPINE AND PANSS SCALE IN PATIENTS WITH SCHIZOPHRENIA POORLY RESPONSIVE TO CLASSIC NEUROLEPTIQUES Phung Thanh Hai*; Bui Quang Huy**; Cao Tien Duc** SUMMARY Objectives: To evaluate the treatment result of clozapine in schizophrenic patients respond poorly to classic neuroleptiques. Subjects and methods: A prospective, cross-sectional, caseby-case analysis on 61 schizophrenic inpatients who responded poorly to classic haloperidol, aged 16 to 55 years and received treatment at National Psychiatric Hospital No 1 between 2014 and 2017. The data were processed by medical statistics using program SPSS Version 17. Result: PANSS scores were significantly different before and after clozapine treatment. Scores of P-PANSS, N-PANSS, G-PANSS and S-PANSS at three surveys were different with statistical significance. Haloperidol and clozapine had a positive correlation but very weak between dose and plasma levels. Conclusion: PANSS scores in patients with schizophrenia, who responded poorly to haloperidol, were significantly different before and after clozapine treatment. * Keywords: Schizophrenia; Classic neuroleptiques; Clozapine; PANSS scale. INTRODUCTION Schizophrenia is a group of severely psychotic disorders. The incidence of schizophrenia ranged from 0.3 to 1.5% of the population. Approximately 30 - 40% of patients with schizophrenia respond poorly or do not respond to classic neuroleptique. Symptoms in these patients did not improve after 4 weeks of treatment with classic antipsychotics. These patients must be treated with clozapine. Sadock B.J (2015) argues that there is a strong correlation between dose of clozapine and therapeutic efficacy [4]. Therefore, dose of clozapine should be carefully monitored so that dosages can be adjusted to improve therapeutic efficacy. In Vietnam, there haven’t even been any studies on the association between dose of clozapine and the results of .
