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Objectives: To investigate clinical, subclinical features and expression of VEGF gene in nonsmall cell lung cancer in order to accurately diagnose the disease at an earlier stage, before the disease has developed, which can lead to a worse prognosis. Subjects and methods: One hundred patients with non-small cell lung cancer and 51 healthy subjects participated in an analytical cross-sectional study with comparison group. | Journal of military pharmaco-medicine n09-2018 STUDY CLINICAL, PARALCINICAL FEATURES AND EXPRESSION OF VEGF GENE IN SERUM OF PATIENTS WITH NON-SMALL CELL LUNG CANCER Ho Van Son1,2; Ngo Tat Trung3; Nguyen Linh Toan1 SUMMARY Objectives: To investigate clinical, subclinical features and expression of VEGF gene in nonsmall cell lung cancer in order to accurately diagnose the disease at an earlier stage, before the disease has developed, which can lead to a worse prognosis. Subjects and methods: One hundred patients with non-small cell lung cancer and 51 healthy subjects participated in an analytical cross-sectional study with comparison group. Results: The relative expression mRNA of the VEGF gene in the study group was significantly higher compared with the control group (p 0.05). 4. The diagnostic value of lung cancer of serum mRNA VEGF expression. Analysis of the diagnostic value of serum mRNA VEGF expression for lung cancer, we analyzed the area under the mRNA VEGF expression curve between lung cancer patients and healthy people (figure 2). Figure 2: The area under the AUC curve expressing of serum mRNA VEGF. The mRNA VEGF expression level in serum was capable of distinguishing patients with lung cancer and healthy people by the area under the AUC curve reached 0.615 (sensitivity 0.7, specificity 0.56, p = 0.05). 104 Journal of military pharmaco-medicine n09-2018 DISCUSSION Primary lung cancer is one of the most common types of malignancy and is the leading cause of death in cancer. Our research showed that the mRNA expression of VEGF gene in the serum of lung cancer patients was significantly higher than that of healthy individuals. This suggested that determining the level of VEGF gene expression in plasma may be one of the potential non-invasive methods for the screening of lung cancer. Of all the vascular factors involved the process of vessel formation related to tumor, VEGF is known to be one of the most important factors in normal physiological and .
