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Two biflavones, podocarpusflavone A (1) and amentoflavone (2) and two megastigmane glycosides, byzantionoside B (3) and (6S,9R)-roseoside (4) were isolated from the methanol extract of the leaves of Antidesma bunius. Their structures were determined by spectroscopic methods and in comparison with the published data. | Vietnam Journal of Chemistry, International Edition, 54(4): 434-438, 2016 DOI: 10.15625/0866-7144.2016-00342 Biflavones and megastigmane glycosides from the leaves of Antidesma bunius Do Thi Trang1, Le Thi Huyen2, Dan Thi Thuy Hang1, Nguyen Xuan Nhiem1, Pham Hai Yen1, Bui Huu Tai1, Hoang Le Tuan Anh1, Chau Van Minh1, Phan Van Kiem1* 1 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 2 Faculty of Chemistry, University of Science, Vietnam National University Received 3 September 2015; Accepted for publication 12 August 2016 Abstract Two biflavones, podocarpusflavone A (1) and amentoflavone (2) and two megastigmane glycosides, byzantionoside B (3) and (6S,9R)-roseoside (4) were isolated from the methanol extract of the leaves of Antidesma bunius. Their structures were determined by spectroscopic methods and in comparison with the published data. Keywords. Antidesma bunius, Euphorbiaceae, biflavone, megastigmane. 1. INTRODUCTION Antidesma bunius (L.) Spreng belongs to Euphorbiaceae family and widely distributes throughout Vietnam and China. The fruits of A. bunius are edible and have been used to prepare drink supplement or healthy foods. In traditional medicine, A. bunius was used for the treatment of inflammation and infection diseases [1]. Phytochemical analysis of this plant indicated the presence of flavonoids, phenolics and organic acids [2]. In addition, this plant exhibited antioxidant [3] and antimicrobial activities [4]. Herein, we report the isolation and structure elucidation of two biflavones and two megastigmane glycosides from the methanol extract of A. bunius leaves. 2. MATERIAL AND METHODS 2.1. Plant material The leaves of Antidesma bunius (L.) Spreng were collected in Daklak province, Vietnam, in March 2013, and identified by Dr. Nguyen Quoc Binh, Vietnam National Museum of Nature. A voucher specimen (AB1303) was deposited at Institute of Marine Biochemistry, VAST. 2.2. General experimental procedures All NMR .
