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Part 1 book “Sherlock’s diseases of the liver and biliary system” has contents: Anatomy and function, liver function in health and disease, biopsy of the liver, coagulation in cirrhosis, acute liver failure, hepatic fibrogenesis, hepatic cirrhosis, hepatic encephalopathy in patients with cirrhosis, and other contents. | Table of Contents Cover Preface to the Thirteenth Edition Preface to the First Edition Chapter 1: Anatomy and Function Development of the liver and bile ducts Anatomy of the liver Functional liver anatomy: sectors and segments Anatomical abnormalities of the liver Anatomy of the biliary tract (Fig. 1.6) Surface marking (Fig. 1.7, Fig. 1.8) Methods of examination Microanatomy of the liver Hepatic ultrastructure (electron microscopy) and organelle functions Functional heterogeneity of the liver (Fig. 1.20) Dynamics of the hepatic microenvironment in physiology and disease (Fig. 1.21) Hepatocyte death and regeneration (Fig. 1.22) References Chapter 2: Liver Function in Health and Disease Bilirubin metabolism (see Chapter 13) Bile acids Lipid and lipoprotein metabolism Amino acid metabolism Plasma proteins Carbohydrate metabolism Markers of hepatocellular injury: the serum transaminases Markers of cholestasis: alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) Haematology in liver disease 2 Effects of ageing on the liver References Chapter 3: Biopsy of the Liver Selection and preparation of the patient Techniques Risks and complications Sampling variability Naked eye appearances Preparation of the specimen Interpretation: a stepwise diagnostic approach Indications (Table 3.4) [5] Special methods [34] References Chapter 4: Coagulation in Cirrhosis Introduction Normal coagulation pathways: a hepatologist’s perspective The coagulation system in cirrhosis Bleeding and thrombosis in cirrhosis Clinical laboratory tests of the coagulation system in cirrhosis Conclusion References Chapter 5: Acute Liver Failure Definition Epidemiology and aetiologies (Fig. 5.1, Table 5.1) Clinical features Initial investigations Complications and management of acute liver failure Specific therapies Prognosis Liver transplantation (Chapter 37) Conclusion References 3 Chapter 6: Hepatic Fibrogenesis Introduction Natural history of hepatic fibrosis Cellular and molecular .
