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Using combined chromatographic methods, four compounds were isolated from the nhexane and ethyl acetate extracts of the Ricinus communis in Melinh - Hanoi. Their structures were determined to be lupeol (1), epialeuritolic acid (2), ergosterol peroxide (3), and ricinine (4) by 1D-, 2D-NMR spectroscopic methods and in comparison with those reported in literature. | Journal of Science and Technology 54 (2C) (2016) 523-529 CONTRIBUTION TO RESULTS OF THE CHEMICAL CONSTITUENTS OF RICINUS COMMUNIS Tran Thi Hoai Van1, 2, Luan Thi Thu1, Do Tien Lam1, Cam Thi Inh1, Lanh Thi Ngoc2, Nguyen Van Tuyen Anh1, Pham Thi Hong Minh1, *, Pham Quoc Long1 1 Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 2 3 Vietnam University of Traditional Medicine, No.2, Tran Phu, Ha Dong, Hanoi Thai Nguyen University of Agriculture and Forestry, Quyet Thang Commune, Thai Nguyen * Email: minhhcsh@gmail.com Received: 15 June 2016; Accepted for publication: 29 October 2016 ABSTRACT Using combined chromatographic methods, four compounds were isolated from the nhexane and ethyl acetate extracts of the Ricinus communis in Melinh - Hanoi. Their structures were determined to be lupeol (1), epialeuritolic acid (2), ergosterol peroxide (3), and ricinine (4) by 1D-, 2D-NMR spectroscopic methods and in comparison with those reported in literature. Keywords: Ricinus communis, triterpenoids, ricinine. 1. INTRODUCTION Ricinus communis (Euphorbiaceae) is widely distributed in Vietnam and leaves are used in the Vietnamese folk medicine to treat several diseases such as pyoderma, eczema, rashes, ulcers, anti-inflammation, anti-arthritis, to kill worms and mosquito larvae [1, 2, 3]. Seed oil is indicated for treatment of constipation in children, pregnant women, patients after surgery and used to treat rectal prolapse, dysentery, pyoderma, lymphadenitis. The roots are used to treat rheumatism arthralgia, pain swelling kicks, tetanus, epilepsy, schizophrenic [1]. Chemical studies on this plant showed the presence of alkaloids, flavonoids, triterpenoids and sterols [4]. Further study on the chemical constituents of Ricinus communis growing in Melinh - Hanoi province, this paper reports the isolation of lupeol (1), epialeuritolic acid (2), ergosterol peroxide (3), and ricinine (4). Their structures were
