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Part 2 book “Red book: 2018–2021 - Report of the committee on infectious diseases” has contents: Summaries of infectious diseases, antimicrobial agents and related therapy, antimicrobial prophylaxis. Invite to reference. | HUMAN IMMUNODEFICIENCY VIRUS INFECTION 459 cidofovir, and foscarnet. Valacyclovir and famciclovir more modestly reduce HHV-8 replication. Retrospective cohort studies and in vitro assays suggest that antiretroviral therapy (particularly zidovudine and nelfinavir) may inhibit HHV-8 replication. Antiviral therapy may play a more significant role in the treatment of diseases associated with active HHV-8 replication, specifically MCD and KICS. HHV-8 associated malignancies can be treated with radiation and cancer chemotherapies. ISOLATION OF THE HOSPITALIZED PATIENT: Standard precautions are recommended. CONTROL MEASURES: Although there are no standard guidelines on preventing HHV-8 transmission, the extensive and consistent epidemiologic and virologic data implicating contact with saliva as the primary mode of HHV-8 acquisition have led some experts to recommend that persons at high-risk for the development of KS be counseled to avoid behavioral practices with exposure to saliva. Other experts, however, have questioned the feasibility or efficacy of such a strategy, which has never been evaluated. As such, no recommendations for measures to control transmission of HHV-8 infection can be recommended at this time. Human Immunodeficiency Virus Infection1 CLINICAL MANIFESTATIONS: Human immunodeficiency virus (HIV) infection results in a wide array of clinical manifestations. HIV type 1 (HIV-1) is much more common in the United States than HIV type 2 (HIV-2). Unless otherwise specified, this chapter addresses HIV-1 infection. Acquired immunodeficiency syndrome (AIDS) is the name given to an advanced stage of HIV infection based on specific criteria for children, adolescents, and adults established by the Centers for Disease Control and Prevention (CDC). Acute retroviral syndrome develops in 50% to 90% of adolescents and adults within the first few weeks after they become infected with HIV. Acute retroviral syndrome is characterized by nonspecific mononucleosis-like .