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The analgesic effect of the ethanolic whole plant extract of Matricaria aurea L. (Asteraceae) was studied in rats using the cold water tail flick assay and in mice using the tail immersion, tail clip, acetic-acid-induced writhing, and formalin pain tests. | E. QNAIS Turk J Biol 35 (2011) 347-352 © TÜBİTAK doi:10.3906/biy-0909-22 The analgesic effect of the ethanolic extract of Matricaria aurea Esam QNAIS Department of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa - JORDAN Received: 12.09.2009 Abstract: The analgesic effect of the ethanolic whole plant extract of Matricaria aurea L. (Asteraceae) was studied in rats using the cold water tail flick assay and in mice using the tail immersion, tail clip, acetic-acid-induced writhing, and formalin pain tests. The results showed dose-dependent and significant (P 0.001) different from that produced by 300 mg/kg of the extract. Table 1. Effect of ethanolic extract of Matricaria aurea on acetic-acid-induced writhing test. Group Dose (mg/kg) No. of writhes (per 30 min) Inhibition (%) Control ---- 73.4 ± 0.49 ---- Matricaria aurea 100 67.2 ± 0.99* 8.45 200 62.1 ± 1.49* 15.4 300 53.2 ± 0.31* 27.5 100 25.2 ± 1.13* 65.7 Aspirin Values are means ± S.E.M. * P < 0.001, significantly different from control; Student’s t-test (n = 5). Table 2. Effect of ethanolic extract of Matricaria aurea on tail flick test. Group Dose (mg/kg) Pre-treatment (s) Post-treatment (s) Inhibition (%) Control ---- 22.3 ± 0.51 22.4 ± 1.42 ---- Matricaria aurea 100 21.1 ± 0.75 19.9 ± 1.66 5.7 200 22.2 ± 1.19 26.4 ± 0.88* 18.9 300 21.4 ± 1.49 33.1 ± 0.60* 35.4 10 22.9 ± 0.44 40.8 ± 3.32* 78.2 Morphine Values are means ± S.E.M. * P < 0.001, significantly different from control; Student’s t-test (n = 5). 349 The analgesic effect of the ethanolic extract of Matricaria aurea Table 3. Effect of ethanolic extract of Matricaria aurea on tail immersion test. Group Dose (mg/kg) Pre-treatment (s) Post-treatment (s) Inhibition (%) Control ---- 2.3 ± 0.72 2.4 ± 0.42 ---- Matricaria aurea 100 2.1 ± 0.35 2.0 ± 0.66 4.8 200 2.2 ± 1.2 2.6 ± 0.78* 18.1 300 2.1 ± 1.6 2.9 ± 0.60* 38.1 10 2.2 ± 0.4 3.6 ± .
