TAILIEUCHUNG - Hydrogels in Regenerative Medicine

If you take a drug that makes you feel a little woozy, you should auto- matically adjust or limit your driving to stay safe. Problems can result when physiological changes of aging combine with drugs commonly prescribed for older adults. Those prescription drugs are the ones most likely to increase the risk of driving problems and accidents. Don’t ignore your body’s reactions when you’re on any medicines. If you feel drowsy, dizzy, nauseous, or headachy, you should not try to drive. . | ADVANCED MATERIALS Hydrogels in Regenerative Medicine By Brandon V. Slaughter Shahana S. Khurshid Omar Z. Fisher Ali Khademhosseini and Nicholas A. Peppas Dedicated to Professor Robert Langer on the occasion of his 60th birthday Hydrogels due to their unique biocompatibility flexible methods of synthesis range of constituents and desirable physical characteristics have been the material of choice for many applications in regenerative medicine. They can serve as scaffolds that provide structural integrity to tissue constructs control drug and protein delivery to tissues and cultures and serve as adhesives or barriers between tissue and material surfaces. In this work the properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed. Recent research involving several different hydrogels polymerized from a variety of synthetic and natural monomers using typical and novel synthetic methods are highlighted. Finally special attention is given to the microfabrication techniques that are currently resulting in important advances in the field. 1. Introduction Since the seminal tissue engineering work by Vacanti et al. 1 in the late 1980s many important advancements have brought this field ever closer to achieving its potential as a life-saving and life-improving option for countless patients where truly suitable Prof. N. A. Peppas Biomaterials Drug Delivery Bionanotechnology and Molecular Recognition Laboratories Department of Chemical Engineering C0400 The University of Texas at Austin Austin TX 78712 USA E-mail peppas@ Prof. N. A. Peppas Department of Pharmaceutics C0400 The University of Texas at Austin Austin TX 78712 USA Prof. N. A. Peppas B. V. Slaughter S. S. Khurshid Dr. O. Z. Fisher Department of Biomedical Engineering C0800 The University of Texas at Austin Austin TX 78712 USA Prof. A. Khademhosseini Center for Biomedical Engineering Department of

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