TAILIEUCHUNG - A prospective interventional study investigating sleep disorders prior to and during adjuvant radiotherapy for breast cancer

Most breast cancer patients with non-metastatic disease receive adjuvant local or loco-regional radiotherapy. To be scheduled for irradiation may cause distress and fears that can lead to sleep disorders. Few reports focused on sleep problems in patients assigned to radiotherapy. | Rades et al. BMC Cancer 2021 21 1349 https s12885-021-09084-w STUDY PROTOCOL Open Access A prospective interventional study investigating sleep disorders prior to and during adjuvant radiotherapy for breast cancer Dirk Rades1 Carlos A. Narvaez2 Liesa Dziggel3 Stefan Janssen4 Denise Olbrich5 Soeren Tvilsted6 and Troels W. Kjaer7 Abstract Background Most breast cancer patients with non-metastatic disease receive adjuvant local or loco-regional radiotherapy. To be scheduled for irradiation may cause distress and fears that can lead to sleep disorders. Few reports focused on sleep problems in patients assigned to radiotherapy. This study evaluates the course of sleep disorders during adjuvant radiotherapy for primary breast cancer and potential risk factors including the use of smartphones or tablets at bedtime. Methods The main goal is the evaluation of sleep disorders prior to radiotherapy and after 15 fractions of radio- therapy. A potential effect of habituation to the procedure of radiotherapy can be assumed that will likely lead to improvement decrease of sleep disorders. Improvement of sleep disorders compared to baseline before radio- therapy is defined as decrease of the severity of sleep disorders by 2 points on a patient self-rating scale 0 no problems 10 maximum problems or decrease of distress caused by sleep disorders by 2 points on a self-rating scale 0 no distress 10 maximum distress or reduction of the dose of sleeping drugs by 25 . Additional end- points include sleep disorders after 5 fractions and at the end of radiotherapy. Moreover potential risk factors includ- ing the use of smartphones or tablets at bedtime are evaluated. Fifty-one patients 48 plus potential drop-outs are required. With this sample size a one-sample binomial test with a one-sided significance level of has a power of 80 to yield statistical significance if the rate of patients with improvement of sleep disorders is 25 rate under the alternative hypothesis .

• Y khoa - Dược
• BMC Cancer
• Breast cancer
• Adjuvant radiotherapy
• Sleep disorders
• Prospective study
• Loco regional radiotherapy
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study