TAILIEUCHUNG - Lecture Microbiology - Chapter 13: Antimicrobial therapy

Lecture Microbiology - Chapter 13: Antimicrobial therapy. This chapter presents the following content: Chemotherapy, antimicrobial drug properties, drug target sites, kinds of drug side effects, drug resistance, mechanisms of resistance, novel enzyme activity,. | ANTIMICROBIAL THERAPY CHAPTER 13 Copyright © 2012 John Wiley & Sons, Inc. All rights reserved. Chemotherapy Antibiotics Synthetics Semi-synthetics Copyright © 2012 John Wiley & Sons, Inc. All rights reserved. History Ancient remedies – Molds in Egyptian times – Quinine Ehrlich – Salvarsan Domagk – Dyes led to discovery of sulfa drugs Fleming – Penicillium mold Copyright © 2012 John Wiley & Sons, Inc. All rights reserved. Antimicrobial Drug Properties Selective Toxicity Activity Spectrum – Broad vs. Narrow Copyright © 2012 John Wiley & Sons, Inc. All rights reserved. Drug Target Sites Cell wall – Peptidoglycan – Mycolic acid – Fungal beta glucans Cell membrane – Some bacterial proteins – Ergosterol Protein synthesis – 70S ribosomes Nucleic acid synthesis – DNA gyrase – RNA - viral enzymes Antimetabolite – Bacterial folic acid Copyright © 2012 John Wiley & Sons, Inc. All rights .

• Sinh học
• Lecture Microbiology
• Roles of microbes
• Biological research
• Antimicrobial therapy
• Antimicrobial drug properties
• Drug target sites
• Environmental microbiology
• Energy flow
• Biogeochemical cycles
• Applied microbiology
• Microbes found in food
• Mesophilic canned spoilage
• Biological research uses microbes
• Microbial abundance
• Prokaryotic microbes
• Fundamentals of chemistry
• Atomic structure
• Chemical building blocks
• Metric units
• Light properties
• Compound light microscopy
• Characteristics of prokaryotic
• Eukaryotic cells
• Cellular characteristics
• Prokaryotic cells
• Microbial metabolism
• Energy capture
• Enzymes control metabolic pathways
• Culturing of bacteria
• Cell division
• Bacterial growth curve
• Counting large populations
• Microbial genetics
• Genetic information storage
• DNA structure
• DNA concepts
• Gene transfer
• Genetic engineering
• Plasmid types
• Taxonomic heirarchy
• Taxonomic keys
• Kingdom protista
• Infectious properties
• Virus classification
• Unique RNA virus cycle
• Eukaryotic microorganisms
• Parasite evasion strategies
• Plant like protozoan phyla
• Aseptic principles
• Controlling microbial growth
• Chemical antimicrobials
• Disease processes
• Symbiotic relationships
• Host invasion
• Nosocomial infections
• Infectious disease spread
• Epidemiological terms
• Innate host defenses
• Innate defense
• Cellular defenses
• Adaptive immunity
• Antigen characteristics
• Immune system properties
• Immune disorders
• Immunological tests precipitin
• immunodiffusion plates
• Mucous membranes
• Bacterial skin diseases
• Staphylococcus aureus
• Gastrointestinal diseases
• Bacterial oral cavity disease
• Bacterial gastrointestinal intoxications
• Systemic diseases
• Bacterial septicemias
• Streptococcal diseases
• Nervous system
• Bacterial diseases
• Bacterial meningitis
• Medical assisting
• Clinical procedures
• Administrative medical assisting
• Clinical medical assisting
• Introduction to microbiology
• Bacterial classification