TAILIEUCHUNG - Lecture Principles of biochemistry - Chapter 7 (part 1): Cofactors

In this chapter, students will be able to understand: Understand what are essential Ions Cofactors; understand how metal ions can function as electrophiles in active site; define coenzyme, cosubstrate, prosthetic group, metabolite coenzymes, Vitamin; know what Vitamin corresponds to what coenzyme;. | Chapter 7 (part 1) Cofactors Cofactors Cofactors are organic or inorganic molecules that are required for the activity of a certain conjugated enzymes Apoenzyme = enzyme (-) cofactor Holoenzyme = enzyme (+) cofactor Inorganic cofactors – essential ions Organic cofactors – coenzymes Essential Ion Cofactors Activator ions – bind reversibly to enzyme and often participate in substrate binding. Metal ions of metalloenzymes – cations that are tightly bound to enzyme and participate directly in catalysis (Fe, Zn, Cu, Co). Metal activated enzymes – require or are stimulated by addition of metal ions (. Mg2+, is required by many ATP requiring enzymes) Metal ions can function as electrophiles in active site Zinc protease (angiotensin converting enzyme) Coenzymes Cosubstrates- - altered in rxn and regenerated to original structure in subsequent rxn - disassociated from active site - shuttle chemical groups among different enzyme rxns. Prosthetic groups- - remains bound to enzyme - must .

• Sinh học
• Principles of biochemistry
• Lecture Principles of biochemistry
• Biological systems
• Biochemical compounds
• Ions Cofactors
• Metal ion
• Ebook Principles of biochemistry
• Principles of biochemistry (4th edition)
• The glyoxylate cycle
• Fatty acid catabolism
• Electron Transfer reactions
• Evolutionary foundations
• Protein interactions modulated
• Nucleic acid structure
• Biological macromolecules
• Chemical principles
• Properties of water
• Hydrogen bonding
• Amino acids
• Amino acid structure
• Protein purification
• Cell extract
• Protein classification
• Protein 3 Dimensional structure
• Protein folding
• Protein 3 D structure
• 3 D structure
• Oxygen binding curve
• Enzyme kinetics
• Rate constants
• Catalytic Power
• Classes of enzymes
• Inhibitor kinetics
• Enzyme regulation
• Allosteric regulation
• Enzyme action
• Mechanisms of enzyme action
• Nguyên lý hóa sinh
• Biotin cofactor
• Conformation of monosaccharides
• Carbohydrate classifications
• Oligo carbohydrate
• Polysaccharides carbohydrate
• Lipid subclasses
• Acyl lipids
• Fluid mosaic model
• membrane transporters
• Metabolism proceed
• Anaeorbic process
• Triose Phosphate Isomerase
• Regulation of glycolysis
• Control points in glycolysis
• Citric acid cycle
• TCA cycle