TAILIEUCHUNG - Lecture Molecular biology: Chapter 17 - Robert F. Weaver

Chapter 17 - The mechanism of translation I: Initiation. This chapter concerns the initiation of translation in eukaryotes and bacteria. Because the nomenclatures of the two systems are different, it is easier to consider them separately. Therefore, let us begin with a discussion of the simpler system, initiation in bacteria. Then we will move on to the more complex eukaryotic scheme. | Molecular Biology Fourth Edition Chapter 17 The Mechanism of Translation I: Initiation Lecture PowerPoint to accompany Robert F. Weaver Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Initiation of Translation in Bacteria Two important events must occur before translation initiation can take place Generate a supply of aminoacyl-tRNAs Amino acids must be covalently bound to tRNAs Process of bonding tRNA to amino acid is called tRNA charging Dissociation of ribosomes into their two subunits The cell assembles the initiation complex on the small ribosomal subunit The two subunits must separate to make assembly possible 17- tRNA Charging All tRNAs have same 3 bases at 3’-end (CCA) Terminal adenosine is the target for charging with amino acid Amino acid attached by ester bond between Its carboxyl group 2’- or 3’-hydroxyl group of terminal adenosine of tRNA 17- Two-Step Charging Aminoacyl-tRNA synthetases join amino acids to their .

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