TAILIEUCHUNG - Further Study on Chemical Constituents of Croton tonkinensis Gagnep., Euphorbiaceae

Croton tonkinensis Gagnep., commonly named in Vietnamese as "Kho sam Bac Bo", is a tropical shrub native to the Northern Vietnam. Its dried leaves (Folium Tonkinensis) have been used in Vietnamese traditional medicine to treat boils, abscesses, impetigo, abdominal pain, dyspepsia, dysentery, gastric and duodenal ulcers [1, 2]. The plant is of our interest since its varied biological activities demonstrated in our various in vitro bioassays including anti-inflammatory, anticancer, antiplasmodial, antibacterial and antifungal. | Journal of Chemistry Vol. 41 No. 1 P. 1 2003 SHORT COMMUNICATION FURTHER STUDy ON CHEMICAL CONSTITUENTS OF CROTON TQNKINENSIS GAGNEP. EUPHORBIACEAE Received 15-2-2003 PHAN MINH GIANG1 JUNG JOON LEE2 PHAN TONG SON1 1Faculty of Chemistry Vietnam National University Hanoi 2Anticancer Research Laboratory Korea Research Institute of Bioscience and Biotechnology Croton tonkinensis Gagnep. commonly named in Vietnamese as Kho sam Bac Bo is a tropical shrub native to the Northern Vietnam. Its dried leaves Folium Tonkinensis have been used in Vietnamese traditional medicine to treat boils abscesses impetigo abdominal pain dyspepsia dysentery gastric and duodenal ulcers 1 2 . The plant is of our interest since its varied biological activities demonstrated in our various in vitro bioassays including anti-inflammatory anticancer antiplasmodial antibacterial and antifungal. Previously we reported on the isolation and structural determination of a new diterpenoid ent-70-hydroxy-15-oxokaur-16-en-18-yl acetate 3 4 from the ethanol extract of the leaves of C. tonkinensis. Investigation of the methanol extract of the leaves of C. tonkinensis by HPLC coupled with PDA detector revealed the presence of 3 main flavonoids in total of the extract one of which was isolated and structurally identified as tiliroside on the basis of ESIMS 1H NMR 13C NMR spectra 5 . The other constituents of the extract are diterpenoids among which four ent-kaurane-type diterpenoids were isolated and structurally characterized on the basis of ESIMS FABMS 1D and 2D NMR including two new ent-1a-acetoxy-7 14a-dihydroxykaur-16-en- 15-one and ent- 18-acetoxy-7 14ữf-dihydroxykaur-16-en-15-one together with two known ent-7 14a-dihydroxykaur-16-en-15-one 6 and ent-7 p -hydroxy- 15-oxokaur- 16-en-18-yl acetate . The phytosterols -sitosterol stigmasterol and two long chain alkyl alcohols were also isolated from the non-polar parts of the methanol extract. Acknowledgements The authors are .

• Hoá học
• Công nghệ hóa
• Chemical Constituents
• Croton tonkinensis Gagnep
• Thành phần hóa học
• Hóa dược
• Kỹ thuật hệ thống công nghệ hóa học
• Hệ thống công nghệ hóa học
• Công nghệ hóa học
• Tối ưu hóa
• Quá trình công nghệ hóa học
• Phương pháp giải thích
• Quy hoạch toán học
• Phương pháp gradient
• Mô hình hóa công nghệ hóa học
• Nghiên cứu công nghệ hóa học
• Mô tả công nghệ hóa học
• giáo trình công nghệ hóa học
• thiết bị công nghệ hóa học
• bài giảng công nghệ hóa học
• công nghệ hóa chất
• tài liệu công nghệ hóa chất
• áp dụng công nghệ hóa chất
• tìm hiểu công nghệ hóa chất
• nghiên cứu công nghệ hóa chất
• công nghệ hóa dầu
• bài giảng công nghệ hóa dầu
• giáo trình công nghệ hóa dầu
• tài liệu công nghệ hóa dầu
• lý thuyết công nghệ hóa dầu