TAILIEUCHUNG - Condensation of 4-amino-3-(2-methoxy-4-propylphenoxymethylene)-(1H)-1,2,4-triazole-5-thione with some aromatic aldehydes

4-Amino-3-(2-methoxy-4-propylphenoxymethylen)-(1H)-1,2,4-triazole-5-thione was prepared from eugenol in Ocimum Sanetum L. essential oil. A series of 7 imines were synthesized from these key compounds by condensing it with different aromatic aldehydes. The structures of these imines were confirmed by EI MS, IR and NMR spectroscopy, in many cases 2D NMR spectra are also used. | Journal of Chemistry Vol. 45 6 P. 763 - 767 2007 CONDENSATION OF 4-AMINO-3- 2-METHOXy-4-PROPyLPHENOXyMETHyLENE - 1H -1 2 4-TRIAZOLE-5-THIONE WITH SOME ARoMAtiC ALDEHyDES Received 2 January 2007 NGuyEN Huu DINH NGuyEN HIEN Department of Chemistry Hanoi University of Education summARy 4-Amino-3- 2-methoxy-4-propylphenoxymethylen - 1H -1 2 4-triazole-5-thione was prepared from eugenol in Ocimum Sanetum L. essential oil. A series of 7 imines were synthesized from these key compounds by condensing it with different aromatic aldehydes. The structures of these imines were confirmed by EI MS IR and NMR spectroscopy in many cases 2D NMR spectra are also used. I - INTRODUCTION Eugenol is the main component of Ocimum sanetum L. essential oil which is used in Vietnamese folk medicine. Recently the anticarcinogenic effect of eugenol has detected by a simplified short-term technique based on the inhibition of microsomal degranulation of rat liver microsomes in vitro 1 . Many derivatives of eugenol such as vanilin O-methyleugenol and isoeugenol nicotinate are now widely applied in practical 2 5 . During the last two decades substituted 1 2 4-triazole and their derivatives are among the various heterocycles that have received considerable attention from chemists due to their great potential biological activities including antituberculosis anticonvulsant antiinflammatory insecticidal antifungal analgesic and antitumor properties 3 . It is our interest to combine the 1 2 4-triazole ring with a moiety of eugenol and to study spectroscopic and biological properties of the products. In previous paper 4 we reported on the preparation and structure of 4-amino-3- 2- methoxy-4-propylphenoxymethylen - 1H - 1 2 4-triazole-5-thione starting from eugenol herein some imines derived from this compound are described. II - EXPERIMENTAl 4-amino-3- 2-methoxy-4-propylphenoxy-methylen - 1H -1 2 4-triazole-5-thione K This compound was prepared according to the method reported in reference 4 . General .

• Hoá học
• Công nghệ hóa
• Aromatic aldehydes
• Hóa hữu cơ
• Tinh dầu
• Ocimum Sanetum L
• Kỹ thuật hệ thống công nghệ hóa học
• Hệ thống công nghệ hóa học
• Công nghệ hóa học
• Tối ưu hóa
• Quá trình công nghệ hóa học
• Phương pháp giải thích
• Quy hoạch toán học
• Phương pháp gradient
• Mô hình hóa công nghệ hóa học
• Nghiên cứu công nghệ hóa học
• Mô tả công nghệ hóa học
• giáo trình công nghệ hóa học
• thiết bị công nghệ hóa học
• bài giảng công nghệ hóa học
• công nghệ hóa chất
• tài liệu công nghệ hóa chất
• áp dụng công nghệ hóa chất
• tìm hiểu công nghệ hóa chất
• nghiên cứu công nghệ hóa chất
• công nghệ hóa dầu
• bài giảng công nghệ hóa dầu
• giáo trình công nghệ hóa dầu
• tài liệu công nghệ hóa dầu
• lý thuyết công nghệ hóa dầu