TAILIEUCHUNG - Báo cáo Y học: Chromatin remodeling in nuclear cloning

Nuclear cloning is a procedure to create new animals by injecting somatic nuclei into unfertilized oocytes. Recent successes in mammalian cloning with differentiated adult nuclei strongly indicate that oocyte cytoplasm contains unidentified remarkable reprogramming activities with the capacity to erase the previous memory of cell differentiation. At the heart of this nuclear reprogramming lies chromatin remodeling as chromatin structure and function define cell differentiation through regulation of the transcriptional activities of the cells | Eur. J. Biochem. 269 2284-2287 2002 FEBS 2002 doi MINIREVIEW Chromatin remodeling in nuclear cloning Paul A. Wade1 and Nobuaki Kikyo2 1 Department of Pathology Emory University Atlanta GA USA 2Stem Cell Institute and Department of Medicine University of Minnesota Minneapolis MN USA Nuclear cloning is a procedure to create new animals by injecting somatic nuclei into unfertilized oocytes. Recent successes in mammalian cloning with diflerentiated ddlủt nuclei strongly indicate that oocyte cytoplasm contains unidentified remarkable reprogramming activities with the capacity to erase the previous memory of cell differentiation. At the heart of this nuclear reprogramming lies chromatin remodeling as chromatin structure and function define cell differentiation through regulation of the transcriptional activities of the cells. Studies involving the modification of chromatin elements such as selective uptake or release of binding proteins covalent histone modifications including acetylation and methylation and DNA methylation should provide significant insight into the molecular mechanisms of nuclear dedifferentiation and redifferentiation in oocyte cytoplasm. Keywords nuclear cloning chromatin remodeling linker histone histone acetylation histone methylation DNA methylation. INTRODUCTION Differentiated somatic nuclei have the flexibility to dedifferentiate in oocyte cytoplasm and redifferentiate into other multiple lineages during the subsequent embryogenesis. This drastic nuclear plasticity has been repeatedly confirmed by successful nuclear cloning in frogs and several mammalian species over the past half a century reviewed in 1-3 . Although generally only less than 1 of cloned mice survive to adulthood 1 many of the aborted embryos still contain terminally differentiated tissues derived from the injected somatic nuclei establishing that highly efficient reprogramming mechanisms exist in oocyte cytoplasm. Currently the identities of .

• Báo cáo khoa học
• Traditional medicine
• Report medicine
• scientific reports
• immune system
• Antimicrobial
• biosynthesis
• Commercial use
• Tadehagi triquetrum (L ) H Ohashi
• Indigenous medicine in Myanmar
• Medicinal plants
• Calotropis gigantea R
• Br
• Traditional medicinal plants
• Local development in Myanmar
• Important role in health care system
• BMC Chemistry
• Trace analysis
• Dispersive solvent
• Traditional Chinese medicine
• Chinese medicine oral liquid
• Veterinary Medicine
• Herbal Medicine
• Varughese George
• Andrographis paniculata
• Chemical Constituents
• alternative medicine
• diagnostic techniques
• Diagnostic therapies
• Chinese medicine
• Medical herbalism
• Massage therapy review
• Lecture Massage therapy review
• Bodywork assessment
• Massage therapy
• Traditional chinese medicine modality
• Acanthospermum hispidum
• Burkina faso
• Pharmacognosic characterization
• Acanthospermum hispidum (Asteraceae)
• Medicinal plant widely
• Active components
• Plasma protein binding
• Research methods
• Doctoral thesis abstract
• Improving accounting work organization
• Accounting work organization
• Traditional medicine hospitals
• Hanoi city
• Vietnamese traditional medicine
• Medicinal herbs
• Ethnic groups
• Community healthcare
• Mountainous area
• Cultural Perspective
• Modern Medicine
• Funding Perspective
• Traditional Oriental
• medicine
• cell proliferation
• oxidation
• breast cancer
• chemical reaction
• gastric cancer
• hormone medicine
• tumor cells
• biochemical studies
• environmental medicine
• Crystal structure