TAILIEUCHUNG - Lecture Biochemistry (2/e): Chapter 9 - Reginald Garrett, Charles Grisham

Membranes serve a number of essential cellular functions. They constitute the boundaries of cells and intracellular organelles, and they provide a surface where many important biological reactions and processes occur. Membranes have proteins that mediate and regulate the transport of metabolites, macromolecules, and ions. | Chapter 9 Membranes and Cell Surfaces to accompany Biochemistry, 2/e by Reginald Garrett and Charles Grisham All rights reserved. Requests for permission to make copies of any part of the work should be mailed to: Permissions Department, Harcourt Brace & Company, 6277 Sea Harbor Drive, Orlando, Florida 32887-6777 Outline Membranes Structure of Membrane Proteins Membrane and Cell-Surface Polysaccharides Glycoproteins Proteoglycans Membranes Structures with many cell functions Barrier to toxic molecules Help accumulate nutrients Carry out energy transduction Facilitate cell motion Assist in reproduction Modulate signal transduction Mediate cell-cell interactions Spontaneously formed lipid structures Hydrophobic interactions all! Very few lipids exists as monomers Monolayers arrange lipid tails in the air! Micelles bury the nonpolar tails in the center of a spherical structure Micelles reverse in nonpolar solvents Spontaneously formed lipid structures Hydrophobic interactions all! Lipid bilayers can form in several ways unilamellar vesicles (liposomes) multilamellar vesicles (Alex Bangham) The Fluid Mosaic Model S. J. Singer and G. L. Nicolson The phospholipid bilayer is a fluid matrix The bilayer is a two-dimensional solvent Lipids and proteins can undergo rotational and lateral movement Two classes of proteins: peripheral proteins (extrinsic proteins) integral proteins (intrinsic proteins) Motion in the bilayer Lipid chains can bend, tilt and rotate Lipids and proteins can migrate ("diffuse") in the bilayer Frye and Edidin proved this (for proteins), using fluorescent-labelled antibodies Lipid diffusion has been demonstrated by NMR and EPR (electron paramagnetic resonance) and also by fluorescence measurements Membranes are Asymmetric Lateral Asymmetry of Proteins: Proteins can associate and cluster in the plane of the membrane - they are not uniformly distributed in many cases Lateral Asymmetry of Lipids: Lipids can cluster in the plane of .

• Sinh học
• Lecture Biochemistry
• Biological phenomena
• Living systems
• Structure of cells
• Structure of membrane proteins
• Cell surfaces
• Principles of biochemistry
• Lecture Principles of biochemistry
• Biological systems
• Biochemical compounds
• Biological macromolecules
• Chemical principles
• Properties of water
• Hydrogen bonding
• Amino acids
• Amino acid structure
• Protein purification
• Cell extract
• Protein classification
• Protein 3 Dimensional structure
• Protein folding
• Protein 3 D structure
• 3 D structure
• Oxygen binding curve
• Enzyme kinetics
• Rate constants
• Catalytic Power
• Classes of enzymes
• Inhibitor kinetics
• Enzyme regulation
• Allosteric regulation
• Enzyme action
• Mechanisms of enzyme action
• Ions Cofactors
• Metal ion
• Nguyên lý hóa sinh
• Biotin cofactor
• Conformation of monosaccharides
• Carbohydrate classifications
• Oligo carbohydrate
• Polysaccharides carbohydrate
• Lipid subclasses
• Acyl lipids
• Fluid mosaic model
• membrane transporters
• Metabolism proceed
• Anaeorbic process
• Triose Phosphate Isomerase
• Regulation of glycolysis
• Control points in glycolysis
• Citric acid cycle
• TCA cycle
• Additional pathways
• Carbohydrate metabolism
• Electron transport
• Chemosmotic theory