TAILIEUCHUNG - Báo cáo khoa học: Mammalian initiator apoptotic caspases

Caspases are a conserved family of cysteine proteases. They play diverse roles in inflammatory responses and apoptotic pathways. Among the casp-ases is a subgroup whose primary function is to initiate apoptosis. Within their long prodomains, caspases-2, -9 and -12 contain a caspase activation and recruitment domain while caspases-8 and -10 bear death effector domains. | iFEBS Journal REVIEW ARTICLE Mammalian initiator apoptotic caspases Po-ki Ho1 2 3 and Christine J. Hawkins1 2 3 1 Murdoch Children s Research Institute Parkville Victoria Australia 2 Children s Cancer Centre RoyalChildren s Hospital Parkville Victoria Australia 3 Department of Paediatrics University of Melbourne Parkville Victoria Australia Keywords activation apoptosis CARD DED gene knockout models human diseases initiator caspases Correspondence C. Hawkins Murdoch Children s Research Institute RoyalChildren s Hospital Flemington Road Parkville VIC 3052 Australia Fax 61 3 93454993 Tel 61 3 93455823 E-mail Received 24 July 2005 accepted 12 September 2005 Caspases are a conserved family of cysteine proteases. They play diverse roles in inflammatory responses and apoptotic pathways. Among the caspases is a subgroup whose primary function is to initiate apoptosis. Within their long prodomains caspases-2 -9 and -12 contain a caspase activation and recruitment domain while caspases-8 and -10 bear death effector domains. Activation follows the recruitment of the procaspase molecule via the prodomain to a high molecular mass complex. Despite sharing some common features other aspects of the biochemistry substrate specificity regulation and signaling mechanisms differ between initiator apoptotic caspases. Defects in expression or activity of these caspases are related to certain pathological conditions including neurodegenerative disorders autoimmune diseases and cancer. doi It has been more than a decade since the discovery of the interleukin-1b-converting enzyme ICE 1 the first member of a family of enzymes termed caspases. Caspases are an evolutionarily conserved family of cysteine proteases that are responsible for diverse cellular functions including inflammation and apoptosis. Features common to all members in this family of proteases include the catalytic cysteine residue in the active site and the ability .

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