TAILIEUCHUNG - Báo cáo khoa học: Differential expression pattern of the novel serine⁄threonine kinase, STK33, in mice and men

Serine⁄threonine kinase 33 (STK33⁄Stk33) is a recently discovered gene whose inferred amino acid sequence translation displays characters typical for a calcium⁄calmodulin dependent kinase (CAMK). In this study we ana-lysed the STK33⁄Stk33RNA and protein distribution and the localization of the protein. TheSTK33⁄Stk33expression pattern resembles those of some related members of the CAMK ⁄Stk33displays a non-ubiquitous and, in most tissues, low level of expression. | iFEBS Journal Differential expression pattern of the novel serine threonine kinase STK33 in mice and men Alejandro O. Mujica1 Bastienne Brauksiepe1 Sigrid Saaler-Reinhardt2 Stefan Reuss3 and Erwin R. Schmidt1 1 Institute of Molecular Genetics Johannes Gutenberg-University Mainz Germany 2 Institute of Genetics Johannes Gutenberg-University Mainz Germany 3 Department of Anatomy and CellBiology Johannes Gutenberg-University Mainz Germany Keywords serine threonine kinase spermatogenesis STK33 antibody STK33 expression Correspondence E. R. Schmidt Institute of Molecular Genetics Johannes Gutenberg-University . Becherweg 32 D-55099 Mainz Germany Fax 49 6131 3925346 Tel 49 6131 3925748 E-mail eschmidt@ These authors contributed equally to the paper Serine threonine kinase 33 STK33 Stk33 is a recently discovered gene whose inferred amino acid sequence translation displays characters typical for a calcium calmodulin dependent kinase CAMK . In this study we analysed the STK33 Stk33 RNA and protein distribution and the localization of the protein. The STK33 Stk33 expression pattern resembles those of some related members of the CAMK group. STK33 Stk33 displays a non-ubiquitous and in most tissues low level of expression. It is highly expressed in testis particularly in cells from the spermatogenic epithelia. Moreover significant expression is detected in lung epithelia alveolar macrophages horizontal cells in the retina and in embryonic organs such as heart brain and spinal cord. A possible role of STK33 Stk33 in spermatogenesis and organ ontogenesis is discussed. Received 6 May 2005 revised 2 August 2005 accepted 3 August 2005 doi The serine threonine kinase 33 gene STK33 Stk33 was identified by comparative sequencing of human chromosome region and its syntenic region in mouse chromosome 7 1 2 . Chromosome is a gene-rich region of clinical importance because several human diseases including predisposition for .

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