TAILIEUCHUNG - Báo cáo khoa học: A1–Protein Function and Ageing

An overview of the results of our association studies on candi-date genes for human longevity performed in Italian centenarians will be presented. Many genes gave negative results but others showed a positive or negative association with human longevity. Among the last ones a particular attention will be paid to the genes involved in inflammation (IL-6, IL-10, TGFbeta, TLR-4,PPARgamma2), Insulin/IGF-1 signalling pathway and lipid metabolism (Apolipoproteins, CEPT). | Abstracts A1-Protein Function and Ageing A1-001 The genetics of human longevity C. Franceschi CIG Centro Interdipartimentale L. Galvani University of Bologna Bologna Italy. E-mail An overview of the results of our association studies on candidate genes for human longevity performed in Italian centenarians will be presented. Many genes gave negative results but others showed a positive or negative association with human longevity. Among the last ones a particular attention will be paid to the genes involved in inflammation IL-6 IL-10 TGFbeta TLR-4 PPARgamma2 Insulin IGF-1 signalling pathway and lipid metabolism Apolipoproteins CEPT . The data obtained in centenarians and in younger control subjects will be compared with those obtained on the same polymorphisms in patients affected by age related diseases myocardial infarction Alzheimer s disease and type 2 diabetes . The data which suggest a strong role of mitochondrial DNA mtDNA in human longevity and an interaction with nuclear genes will also be reviewed with particular attention to mtDNA haplogroups and the C150T mutation. The identification of new longevity genes in a region of Chromosome 1 very rich of Alu sequences using a novel inter-Alu PCR approach will also be illustrated. Finally the strategy which will be adopted by the EU Integrated Project Genetics of healthy ageing GEHA for the identification of longevity genes in 90 sib-pairs genome scanning and mtDNA re-sequencing will be presented. On the whole the data we obtained until now are compatible with the hypothesis that a major characteristic of the ageing process is the development of a chronic inflammatory status we proposed to call INFLAMM-AGING and with the hypothesis that the genetics of human longevity is quite peculiar being a post-reproductive genetics where antagonistic pleiotropy can play a major role and where genes can have quite different biological role and effects at different ages. 67 Abstracts A1-002 .

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