TAILIEUCHUNG - Báo cáo khoa học: The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw

The budding yeastSaccharomyces cerevisiaepossesses a very flexible and complex programme of gene expression when exposed to a plethora of environmental insults. Therefore, yeast cell homeostasis control is achieved through a highly coordinated mechanism of transcription regulation invol-ving several factors, each performing specific functions. Here, we present our current knowledge of the function of the yeast activator protein family, formed by eight basic-leucine zipper trans-activators, which have been shown to play an important role in stress response | ềFEBS Journal REVIEW ARTICLE The yeast stress response Role of the Yap family of b-ZIP transcription factors The PABMB Lecture delivered on 30 June 2004 at the 29th FEBS Congress in Warsaw Claudina Rodrigues-Pousada Tracy Nevitt and Regina Menezes Genomics and Stress Laboratory Instituto de Tecnologia Quimica e Biologica Universidade Nova de Lisboa Oeiras Portugal Keywords Saccharomyces cerevisae stress response Yap Correspondence C. Rodrigues-Pousada Genomics and Stress Laboratory Instituto deTecnologia Quimica e Biologica Avenida da Republica EAN Apt127 2781-901 Oeiras Portugal Fax 351 2144 11277 Tel 351 2144 69624 E-mail claudina@ Website http Research Biological_Chemistry Genomics_and_Stress Received 2 February 2005 revised 22 March 2005 accepted 1 April 2005 doi The budding yeast Saccharomyces cerevisiae possesses a very flexible and complex programme of gene expression when exposed to a plethora of environmental insults. Therefore yeast cell homeostasis control is achieved through a highly coordinated mechanism of transcription regulation involving several factors each performing specific functions. Here we present our current knowledge of the function of the yeast activator protein family formed by eight basic-leucine zipper trans-activators which have been shown to play an important role in stress response. The capacity for adaptation to changes in intra- and extracellular conditions is a universal prerequisite for an organism s survival and evolution. The existence of molecular mechanisms of response repair and adaptation many of which are greatly conserved across nature endows the cell with the plasticity it requires to adjust to its ever-changing environment a homeostatic event that is termed the stress response. Through the sensing and transduction of the stress signal into the nucleus a genetic reprogramming occurs that leads on the one hand to a decrease in the expression of housekeeping .

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