TAILIEUCHUNG - Báo cáo khoa học: Brain lipid composition in postnatal iron-induced motor behavior alterations following chronic neuroleptic administration in mice

Several studies have shown that deficient uptake or excessive break down of membrane phospholipids may be associated with neurodegenerative and psychiatric disorders. The purpose of the present study was to examine the effects of postnatal iron administration in lipid composition and behavior and whether or not the established effects may be altered by subchronic administration of the neuroleptic compounds, clozapine and haloperidol. | iFEBS Journal Brain lipid composition in postnatal iron-induced motor behavior alterations following chronic neuroleptic administration in mice Giorgis Isaac1 Anders Fredriksson2 Rolf Danielsson1 Per Eriksson3 and Jonas Bergquist1 1 Department of AnalyticalChemistry BiomedicalCenter Uppsala University Sweden 2 Department of Neuroscience Psychiatry Ulleraker Uppsala University Sweden 3 Department of EnvironmentalToxicology Evolutionary Biology Uppsala University Sweden Keywords Neuroleptics neurodegenerative and psychiatric disorders phosphatidylcholine postnataliron treatment sphingomyelin Correspondence J. Bergquist Department of Analytical Chemistry Uppsala University Box 599 SE-751 24 Uppsala Sweden Fax 46 18 4713692 Tel 46 18 4713675 E-mail Present address Division of Biology Kansas State University Manhattan KA USA Received 22 December 2005 revised 23 Feburary 2006 accepted 20 March 2006 doi Several studies have shown that deficient uptake or excessive break down of membrane phospholipids may be associated with neurodegenerative and psychiatric disorders. The purpose of the present study was to examine the effects of postnatal iron administration in lipid composition and behavior and whether or not the established effects may be altered by subchronic administration of the neuroleptic compounds clozapine and haloperidol. In addition to motor activities such as locomotion rearing and activity a targeted lipidomics approach has been used to investigated the brains of eight groups of mice four vehicle groups and four iron groups containing six individuals in each group treated with vehicle low dose clozapine high dose clozapine and haloperidol. Lipids were extracted by the Folch method and analyzed using reversed-phase capillary liquid chromatography coupled on-line to electrospray ionization mass spectrometry LC ESI MS . Identification of phosphatidylcholine PC and sphingomyelin SM molecular species was

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