TAILIEUCHUNG - Báo cáo khoa học: Tumor suppressor p16INK4a ) modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells

Expression of the tumor suppressor p16 INK4a after stable transfection can restore the susceptibility of epithelial tumor cells to anoikis. This property is linked to increases in the expression and cell-surface presence of the fibronectin receptor. Considering its glycan chains as pivotal signals, we assumed an effect of p16 INK4a on glycosylation. | ỊFEBS Journal Tumor suppressor p16INK4a - modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells Sabine Andre1 Hugo Sanchez-Ruderisch2 Hiroaki Nakagawa3 Malte Buchholz4 Jurgen Kopitz5 Pia Forberich6 Wolfgang Kemmner6 Corina Brick1 Kisaburo Deguchi3 Katharia M. Detjen2 Bertram Wiedenmann2 Magnus von Knebel Doeberitz5 Thomas M. Gress7 Shin-Ichiro Nishimura3 Stefan Rosewicz2 and Hans-Joachim Gabius1 1 Institute of PhysiologicalChemistry Faculty of Veterinary Medicine Ludwig-Maximilians-University Munich Germany 2 Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie Charite-Universitatsmedizin Berlin Germany 3 Graduate Schoolof Advanced Life Science Frontier Research Center for Post-Genome Science and Technology Hokkaido University Sapporo Japan 4 Abteilung Innere Medizin I Universitat Ulm Germany 5 Institut fur Angewandte Tumorbiologie Klinikum der Ruprecht-Karls-Universitat Heidelberg Germany 6 Clinic of Surgery and SurgicalOncology Robert Roessle Hospital Charites Campus Buch Berlin Germany 7 Department of Gastroenterology Endocrinology and Metabolism University HospitalGiessen and Marburg Germany Keywords anoikis fibronectin receptor galectin glycosyltransferases pancreas tumor Correspondence S. Andre Institute of Physiological Chemistry Faculty of Veterinary Medicine Ludwig-Maximilians-University Munich Veterinarstr. 13 80539 Munich Germany Fax 49 89 21802508 Tel 49 89 21803279 E-mail Received 21 February 2007 revised 23 March 2007 accepted 27 April 2007 doi Expression of the tumor suppressor p16INK4a after stable transfection can restore the susceptibility of epithelial tumor cells to anoikis. This property is linked to increases in the expression and cell-surface presence of the fibronectin receptor. Considering its glycan chains as pivotal signals we assumed an effect of p16INK4a on .

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