TAILIEUCHUNG - Báo cáo khoa học: Therapeutic targeting of molecules involved in leukocyte–endothelial cell interactions

Inflammation is traditionally viewed as a physiological reaction to tissue injury. Leukocytes contribute to the inflammatory response by the secretion of cytotoxic and pro-inflammatory compounds, by phagocytotic activity and by targeted attack of foreign antigens. Leukocyte accumulation in tis-sues is important for the initial response to injury. | ễFEBS Journal MINIREVIEW Therapeutic targeting of molecules involved in leukocyte-endothelial cell interactions Nicole C. Kaneider1 Andrew J. Leger1 2 and Athan Kuliopulos1 2 3 1 Molecular Oncology Research Institute Tufts-New England MedicalCenter Boston MA USA 2 Department of Medicine Tufts University Schoolof Medicine Boston MA USA 3 Department of Biochemistry Tufts University Schoolof Medicine Boston MA USA Keywords endothelium inflammatory diseases leukocytes therapeutic targets Correspondence A. Kuliopulos Tufts-NEMC 750 Washington St. Box 7510 Boston MA 02111 USA Fax 1 617 636 7855 Tel 1 617 636 8482 E-mail Received 15 May 2006 accepted 12 July 2006 doi Inflammation is traditionally viewed as a physiological reaction to tissue injury. Leukocytes contribute to the inflammatory response by the secretion of cytotoxic and pro-inflammatory compounds by phagocytotic activity and by targeted attack of foreign antigens. Leukocyte accumulation in tissues is important for the initial response to injury. However the overzeal-ous accumulation of leukocytes in tissues also contributes to a wide variety of diseases such as atherosclerosis chronic inflammatory bowel disease rheumatoid arthritis multiple sclerosis vasculitis systemic inflammatory response syndrome juvenile diabetes and psoriasis. Many therapeutic interventions target immune cells after they have already migrated to the site of inflammation. This review addresses different therapeutic strategies used to reduce or prevent leukocyte-endothelial cell interactions and communication in order to limit the progression of inflammatory diseases. One of the key characteristics of inflammation is the recruitment of leukocytes to the site of tissue injury. There are three major subsets of leukocytes with migratory capacity that are involved in inflammation neutrophils monocytes macrophages and lymphocytes. Quiescent endothelium acts as a barrier between the .

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