TAILIEUCHUNG - Báo cáo khoa học: Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine A possible means to regulate gene expression

Chromosomal rearrangements apparently account for the presence of a pri-mate-specific gene (protease serine 3) in chromosome 9. This gene encodes, as the result of alternative splicing, both mesotrypsinogen and trypsino-gen 4. Whereas mesotrypsinogen is known to be a pancreatic protease, neither the chemical nature nor biological function of trypsinogen 4 has been explored previously. | ễFEBS Journal Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine A possible means to regulate gene expression A i o I M A mh 1 pr 1 r 1 I 1 IHI i n Tóth1 Prĩks ĨHÓ HĨ1 phl ÝÝ2 Po h 3 AHila L. Pcici IVIcUVcUZky Julia loth Elika Siklódi IxaLailll SUHIclL AHUlao Panny Miklos Palkovits4 Judit Ovádi5 Natalia Tõkési5 Pctcr Ncmcth6 László Szilagyi1 and László Graf1 3 1 Department of Biochemistry Eotvos Lorand University Budapest Hungary 2 Departments of Physiology and Neurobiology Eotvos Lorand University Budapest Hungary 3 Biotechnology Research Group of the Hungarian Academy of Sciences Budapest Hungary 4 Laboratory of Neuromorphology Department of Anatomy Semmelweis University Budapest Hungary 5 Institute of Enzymology Hungarian Academy of Sciences Budapest Hungary 6 Institute of Immunology and Biotechnology University of Pecs Hungary Keywords brain protein synthesis PRSS3 serine protease translation initiation trypsin 4 Correspondence L. Graf Department of Biochemistry Eotvos Lorand University Pazmany Peter s. 1 C Budapest H-1117 Hungary Fax 36 1 3812172 Tel 36 1 3812171 E-mail graf@ These authors contributed equally to this work Received 7 December 2006 accepted 18 January 2007 doi Summary Chromosomal rearrangements apparently account for the presence of a primate-specific gene protease serine 3 in chromosome 9. This gene encodes as the result of alternative splicing both mesotrypsinogen and trypsinogen 4. Whereas mesotrypsinogen is known to be a pancreatic protease neither the chemical nature nor biological function of trypsinogen 4 has been explored previously. The trypsinogen 4 sequence contains two predicted translation initiation sites an AUG site that codes for a 72-residue leader peptide on Isoform A and a CUG site that codes for a 28-residue leader peptide on Isoform B. We report studies that provide evidence for the N-terminal amino acid sequence of

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