TAILIEUCHUNG - Báo cáo khoa học: Gene silencing at the nuclear periphery

The nuclear envelope (NE) is composed of inner and outer nuclear mem-branes (INM and ONM, respectively), nuclear pore complexes and an underlying mesh like supportive structure – the lamina. It has long been known that heterochromatin clusters at the nuclear periphery adjacent to the nuclear lamina, hinting that proteins of the lamina may participate in regulation of gene expression. | ỊFEBS Journal MINIREVIEW Gene silencing at the nuclear periphery Sigal Shaklai Ninette Amariglio Gideon Rechavi and Amos J. Simon Sheba Cancer Research Center and the Institute of Hematology The Chaim Sheba MedicalCenter TelHashomer and the Sackler Schoolof Medicine TelAviv University Israel Keywords epigenetics gene silencing heterochromatin histone modifications LAP2 laminopathies nuclear envelope nuclear envelopathies nuclear lamina transcription Correspondence A. J. Simon Sheba Cancer Research Center and the Institute of Hematology The Chaim Sheba MedicalCenter TelHashomer and the Sackler Schoolof Medicine TelAviv University Israel Fax 972 3 530 5351 Tel 972 3 530 5814 E-mail Received 21 August 2006 revised 4 January 2007 accepted 8 January 2007 doi The nuclear envelope NE is composed of inner and outer nuclear membranes INM and ONM respectively nuclear pore complexes and an underlying mesh like supportive structure - the lamina. It has long been known that heterochromatin clusters at the nuclear periphery adjacent to the nuclear lamina hinting that proteins of the lamina may participate in regulation of gene expression. Recent studies on the molecular mechanisms involved show that proteins of the nuclear envelope participate in regulation of transcription on several levels from direct binding to transcription factors to induction of epigenetic histone modifications. Three INM proteins lamin B receptor lamina-associated polypeptide 2b and emerin were shown to bind chromatin modifiers and or transcriptional repressors inducing at least in one case histone deacetylation. Emerin and another INM protein MAN1 have been linked to down-regulation of specific signaling pathways the retino blastoma 1 E2F MyoD and transforming growth factor beta bone morphogenic protein respectively. Therefore cumulative data suggests that proteins of the nuclear lamina regulate transcription by recruiting chromatin .

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