TAILIEUCHUNG - Báo cáo khoa học: Nucleoplasmic lamins and their interaction partners, LAP2a, Rb, and BAF, in transcriptional regulation

Lamins are major structural components of the nuclear envelope in multi-cellular eukaryotes. Particularly A-type lamins are also located in the nucleoplasm, likely involving a specific binding partner, lamina-associated polypeptide 2a (LAP2a). LAP2a–lamins A⁄C complexes in the nucleo-plasm have been implicated in the regulation of gene expression by various means. | MINIREVIEW Nucleoplasmic lamins and their interaction partners LAP2a Rb and BAF in transcriptional regulation Daniela Dorner Josef Gotzmann and Roland Foisner Max F. Perutz Laboratories Department of MedicalBiochemistry MedicalUniversity of Vienna Austria Keywords BAF cell cycle chromatin organization epigenetics lamina-associated proteins laminopathies lamins LEM-domain nuclear architecture Correspondence R. Foisner Max F. Perutz Laboratories Department of MedicalBiochemistry MedicalUniversity of Vienna Dr Bohrgasse 9 3 A-1030 Vienna Austria Fax 43 1 4277 9616 Tel 43 1 4277 61680 E-mail Lamins are major structural components of the nuclear envelope in multicellular eukaryotes. Particularly A-type lamins are also located in the nucleoplasm likely involving a specific binding partner lamina-associated polypeptide 2a LAP2a . LAP2a-lamins A C complexes in the nucleoplasm have been implicated in the regulation of gene expression by various means. They bind chromatin proteins and chromatin modifying enzymes and can thus participate in epigenetic control pathways. Furthermore binding of lamins A C complexes to specific transcription factors and repressors may directly affect their transcriptional activity. LAP2a-lamins A C also regulate retinoblastoma protein and influence cell cycle progression and differentiation which could have important implications for molecular mechanisms of laminopathic diseases linked to lamins A C mutations. Received 3 March 2006 accepted 8 January 2007 doi The nuclear specific intermediate filament-type proteins the lamins 1 2 are major structural proteins of the nuclear envelope NE forming the nuclear lamina network at the nucleoplasmic surface of the inner nuclear membrane. There they bind to integral membrane proteins 3 4 to DNA and chromatin proteins 5-9 thus providing mechanical stability for the nuclear envelope and organizing chromatin structure at the nuclear periphery. .

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