TAILIEUCHUNG - Báo cáo khoa học: Growth hormone/JAK-STAT axis signal-transduction defect A novel treatable cause of growth failure

Primary cultured fibroblasts of four patients with idiopathic short stature and severe growth delay, which displayed normal growth hormone receptor expression presented a reduced ability for activation of signal transducer and activator of transcription-3 (STAT3). Impaired STAT3 activation was accompanied by cell-cycle arrest at the Go⁄G1 phase. | iFEBS Journal Growth hormone JAK-STAT axis signal-transduction defect A novel treatable cause of growth failure Andrea P. Rojas-Gil1 Panos G. Ziros2 Leonor Diaz2 Dimitris Kletsas3 Efthimia K. Basdra4 Theodore K. Alexandrides5 Zvi Zadik6 Stuart J. Frank7 Vassiliki Papathanassopoulou1 Nicholas G. Beratis1 Athanasios G. Papavassiliou2 and Bessie E. Spiliotis1 1 Division of Pediatric Endocrinology Department of Pediatrics University of Patras Schoolof Medicine Greece 2 Department of Biochemistry University of Patras Schoolof Medicine Greece 3 Institute of Biology NCSR Demokritos Athens Greece 4 Department of Orthodontics Aristotle University of Thessaloniki Greece 5 Division of Endocrinology Department of InternalMedicine University of Patras Schoolof Medicine Greece 6 Division of Pediatric Endocrinology Department of Pediatrics Kaplan MedicalCenter Rehovot Israel 7 Department of Medicine Division of Endocrinology Diabetes and Metabolism University of Alabama at Birmingham and Endocrinology Section MedicalService Veterans Affairs MedicalCenter AL USA Keywords growth hormone growth hormone receptor insulin-like growth factor idiopathic short stature signal transducer and activator of transcription-3 Correspondence B. E. Spiliotis Division of Pediatric Endocrinology Department of Pediatrics University of Patras Schoolof Medicine 26504 Rio-Patras Greece Fax 30 2610 910869 Tel 30 2610 999544 E-mail besspil@ A. G. Papavassiliou Department of Biochemistry School of Medicine University of Patras 26110 Rio-Patras Greece Fax 30 2610 996110 Tel 30 2610 996144 E-mail gpapavas@ Received 13 March 2006 revised 30 April 2006 accepted 31 May 2006 doi Primary cultured fibroblasts of four patients with idiopathic short stature and severe growth delay which displayed normal growth hormone receptor expression presented a reduced ability for activation of signal transducer and activator of transcription-3 STAT3 . Impaired STAT3 .

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