TAILIEUCHUNG - Báo cáo khoa học: Temperature compensation through systems biology

Temperature has a strong influence on most individual biochemical reac-tions. Despite this, many organisms have the remarkable ability to keep certain physiological fluxes approximately constant over an extended tem-perature range. In this study, we show how temperature compensation can be considered as a pathway phenomenon rather than the result of a single-enzyme property. | ễFEBS Journal Temperature compensation through systems biology Peter Ruoff1 Maxim Zakhartsev2 and Hans V. Westerhoff3 4 1 Department of Mathematics and NaturalScience University of Stavanger Norway 2 BiochemicalEngineering InternationalUniversity of Bremen Germany 3 Manchester Centre for Integrative Systems Biology Schoolfor ChemicalEngineering and AnalyticalSciences The University of Manchester UK 4 BioCentre Amsterdam FALW Free University Amsterdam the Netherlands Keywords control coefficients gene expression metabolic regulation systems biology temperature compensation Correspondence P. Ruoff Department of Mathematics and Natural Science Faculty of Science and Technology University of Stavanger N-4036 Stavanger Norway Fax 47 518 41750 Tel 47 518 31887 E-mail Website http ruoff Present address Department of Marine AnimalPhysiology Alfred Wegener Institute for Marine and Polar Research AWI Bremerhaven Germany Temperature has a strong influence on most individual biochemical reactions. Despite this many organisms have the remarkable ability to keep certain physiological fluxes approximately constant over an extended temperature range. In this study we show how temperature compensation can be considered as a pathway phenomenon rather than the result of a singleenzyme property. Using metabolic control analysis it is possible to identify reaction networks that exhibit temperature compensation. Because most activation enthalpies are positive temperature compensation of a flux can occur when certain control coefficients are negative. This can be achieved in networks with branching reactions or if the first irreversible reaction is regulated by a feedback loop. Hierarchical control analysis shows that networks that are dynamic through regulated gene expression or signal transduction may offer additional possibilities to bring the apparent activation enthalpies close to zero and lead to temperature compensation. A calorimetric experiment .

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