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Apart from the multiple alignment construction problem, a fully automatic approach also has to provide a clustering, and to work for multidomain proteins, define domain boundaries. For instance, the Domainer algorithm, 10 which performs the clus- tering of domain families based on all versus all Blastp matching, is a fully automatic approach that was used for building the ProDom database. We are most familiar with the Domainer method but believe that other automated sequence clustering approaches share similar drawbacks. The clustering level of Domainer depends on the score level of accepted pairwise Blastp matches. Domain borders are in- ferred by analyzing the extent of the BLASTmatches and from NH2- and COOH-terminal ends. The main problem with. | ProQuest Dissertations Theses The world s most comprehensive collection of dissertations and theses On-demand digital access to the scholarly record The database of record for graduate research the official respository for the Library of Congress The ProQuest Dissertations Theses PQDT database provides your students with online access to discover nearly 3 million doctoral dissertations and master s theses. More than a thousand new dissertations and theses are added weekly resulting in more than 80 000 new full-text scholarly works every year. The breadth of subject coverage means one subscription will be used across all disciplines and departments. As the database of record for graduate research and the official dissertations repository for the Library of Congress the collection is searched over 200 million times a year at more than 3 000 leading academic institutions worldwide. All dissertations and theses are peer-reviewed assuring you that the collection only contains the best scholarly content. First-ever global access to Chinese graduate works English-language metadata and abstracts of 400 000 Chinese works are being added In June 2012 ProQuest joined forces with China Academic Library and Information System CALIS to provide first-ever global access to abstracts of the graduate output of 80 Chinese Universities. English-language metadata and abstracts of 400 000 works are being added to ProQuest Dissertation and Theses database PQDT enabling researchers to discover them in the context of works from around the world. The agreement with CALIS is the first of several planned initiatives to bring important Asian content to PQDT. China will continue to be a global leader in dissertation creation and ProQuest expects to add metadata for tens of thousands new dissertations and theses each year. Current content being added is focused in Science and Technology including new research in the areas of green energy and sustainability. However researchers in all areas will

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