TAILIEUCHUNG - Aptamer Database

Many examples of P2P systems have emerged recently, most of which are wide-area, large-scale systems that provide content sharing [12], storage services [10], or distributed “grid” computation [4, 11]. Smaller-scale P2P systems also exist, such as federated, serverless file systems [2, 1] and collaborative workgroup tools [7]. The success of these systems has been mixed; some, such as Napster, have enjoyed enormous popularity and perform well at scale. Others, including Gnutella, have failed to attract a large community, possibly due to a combination of weak application semantics and technical flaws that limit its scaling. Perhaps the most exciting possibility of peer-to-peer computing is that the desirable. | Nucleic Acids Research 2004 Vol. 32 Database issue D95-D100 DOI nar gkh094 Aptamer Database Jennifer F. Lee Jay R. Hesselberth1 Lauren Ancel Meyers2 and Andrew D. Ellington Department of Chemistry and Biochemistry Institute for Cell and Molecular Biology University of Texas at Austin 1 University Station A4800 Austin TX 78712 USA 1Department of Genome Sciences University of Washington Health Sciences Building K-2222 Box 357730 Seattle WA 98915 USA and 2Section of Integrative Biology University of Texas at Austin 1 University Station C0930 Austin TX 78712 USA Received August 14 2003 Revised and Accepted October 7 2003 ABSTRACT The aptamer database is designed to contain comprehensive sequence information on aptamers and unnatural ribozymes that have been generated by in vitro selection methods. Such data are not normally collected in natural sequence databases such as GenBank. Besides serving as a storehouse of sequences that may have diagnostic or therapeutic utility the database serves as a valuable resource for theoretical biologists who describe and explore fitness landscapes. The database is updated monthly and is publicly available at http aptamer. . INTRODUCTION Functional nucleic acids can be selected from random sequence libraries. In general in vitro selection mimics natural selection in that a pool of heritable diversity is generated typically by chemical synthesis the pool is sieved for binding or catalysis and successful variants are preferentially ampli ed by some combination of reverse transcription PCR and in vitro transcription 1 5 This process has also been described as the Systematic Evolution of Ligands by EXponential enrichment or SELEX 6 . Nucleic acid binding species generated by in vitro selection have been referred to as aptamers 7 . Aptamers can be RNA modi ed RNA singlestranded DNA or double-stranded DNA and have been selected to bind targets ranging from small organic molecules to entire organisms. Novel nucleic .

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