TAILIEUCHUNG - Báo cáo khoa học: A1 – Ageing

The mechanism of age-related decrease of angiogenic potential in myocardium is still unclear. Cardiac microvascular endothelial cells (CMECs) play a key role in cardiac angiogenesis. In this study, using the CMECs which are isolated from young and old hearts, we found that the migration and proliferation capacity of old CMECs were diminished. | IFEBS Journal A1 - Ageing Abstracts A1 - Ageing Abstract withdrawn BDNF Mediated Angiogenesis Potential is Decreased Associated with Aging D. Cai L. Cao S. Chen D. Li X. Shen X Zheng and X. Liu Ji Nan University Key Laboratory for Regenerative Medicine Minstry of Education Guangzhou China The mechanism of age-related decrease of angiogenic potential in myocardium is still unclear. Cardiac microvascular endothelial cells CMECs play a key role in cardiac angiogenesis. In this study using the CMECs which are isolated from young and old hearts we found that the migration and proliferation capacity of old CMECs were diminished. BDNF was able to increase the migration and proliferation of CMECs no matter in young and old CMECs however the effects in old CMECs was less potent compared with the young CMECs. In vivo study showed that delivery of BDNF in young heart in ischemic situation was able to increase the vessel numbers in both infarct and border zone significantly but not in young heart in non-ischemic situation. The microarray results showed that 84 genes were up-regulated while 81 genes were down-regulated upon BDNF treatment. The functional annotations of genes are cell migration blood vessel morphogenesis angiogenesis regulation of proliferation cell cycle regulation etc which have been shown the strong potential effects in migration proliferation and angiogenesis. The results of present study revealed that BDNF-TrkB pathway play an important role in angiogenesis of myocardium. Although CMECs express BDNF consistently however BDNF might not initiate the angiogenesis in heart individually in vivo. BDNF-mediated angiogenic potential might depend on the cross talk with focal micro-environment. Importantly senescence of CMECs was able to impair the BDNF-mediated migration and proliferation capacity. It might contribute to age-related decrease of angiogenic potential in myocardium and poor regenerative capacity seen in aged heart. Memory enhancing .

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