TAILIEUCHUNG - Báo cáo khoa học: Human lactoferrin activates NF-jB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling

Lactoferrin (LF) has been implicated in innate immunity. Here we reveal the signal transduction pathway responsible for human LF (hLF)-triggered nuclear factor-jB (NF-jB) activation. Endotoxin-depleted hLF induces NF-jB activation at physiologically relevant concentrations in the human monocytic leukemia cell line, THP-1, and in mouse embryonic fibroblasts (MEFs). | ỊFEBS Journal Human lactoferrin activates NF-kB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling Ken Ando1 Keiichi Hasegawa1 Ken-ichi Shindo1 Tomoyasu Furusawa1 Tomofumi Fujino1 Kiyomi Kikugawa1 Hiroyasu Nakano2 Osamu Takeuchi3 Shizuo Akira3 Taishin Akiyama4 Jin Gohda4 Jun-ichiro Inoue4 and Makio Hayakawa1 1 Schoolof Pharmacy Tokyo University of Pharmacy and Life Sciences Japan 2 Department of Immunology Juntendo University Schoolof Medicine Japan 3 Department of Host Defense Research Institute for MicrobialDiseases Osaka University Japan 4 Division of Cellular and Molecular Biology Department of Cancer Biology Institute of MedicalScience The University of Tokyo Japan Keywords human lactoferrin innate immunity lipopolysaccharide nuclear factor-KB NF-kB Toll-like receptor 4 TLR4 Correspondence Makio Hayakawa Schoolof Pharmacy Tokyo University of Pharmacy and Life Science 1432-1 Horinouchi Hachioji Tokyo 192-0392 Japan Fax 81-42-676-4508 Tel 81-42-676-4513 E-mail hayakawa@ Received 26 August 2009 revised 15 February 2010 accepted 18 February 2010 doi Lactoferrin LF has been implicated in innate immunity. Here we reveal the signal transduction pathway responsible for human LF hLF -triggered nuclear factor-KB NF-KB activation. Endotoxin-depleted hLF induces NF-KB activation at physiologically relevant concentrations in the human monocytic leukemia cell line THP-1 and in mouse embryonic fibroblasts MEFs . In MEFs in which both tumor necrosis factor receptor-associated factor 2 TRAF2 and TRAF5 are deficient hLF causes NF-kB activation at a level comparable to that seen in wild-type MEFs whereas TRAF6-deficient MEFs show significantly impaired NF-kB activation in response to hLF. TRAF6 is known to be indispensable in leading to NF-kB activation in myeloid differentiating factor 88 MyD88 -dependent signaling pathways while the role of TRAF6 in the .

• Báo cáo khoa học
• Scientific reports
• scientific research
• molecular Biology
• lipopolysaccharide
• medical research
• immune system
• collection of scientific reports
• industry reports philosophy of history reports
• reports in literature
• a scientific b shirt
• presentation of scientific reports
• reports on literature
• philosophy statement
• documents
• studies English language and English language communication and English language commercial
• progress reports at scientific collections
• agronomic reports
• reports in physics
• biology reports
• thematic biological
• induced geometry
• mathematical topics
• quantum mechanics
• physics
• reporting mathematics
• physics reports
• livestock reports
• physical reports
• research physicist
• specializing in physics
• mathematical statements
• mathematical equations
• English pronunciation
• presentation report
• agricultural reports
• technical crops
• bio technology
• English reports
• presentation reports
• mathematical knowledge
• reports of mathematics
• represented
• Wilf on packing distinct
• Tur´n density
• mathematical works
• patterns in a permutation
• statements and documents scientific reports
• reports agronomy
• biotechnology
• plants Vietnam
• specialized biological
• microbiological methods
• presenting the report
• anti bacterial properties of shrimp
• energy exchange
• engineering chicken
• Path counting
• random matrix theory
• Even circuits
• prescribed clockwise parity
• Correspondence between
• algorithmic characterizations
• Finding Induced Acyclic
• Random Digraphs
• Nonexistence results
• Hadamard like matrices
• Voltage Graphs
• Group Presentations
• Cages mathematical knowledge
• Dominance Order
• Graphical Partitions
• On the functions
• values in [α(G
• Box With Translates
• Two Given Rectangular Brick
• On the q analogue
• the sum of cubes