TAILIEUCHUNG - Báo cáo y học: "Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery. | Available online http content 13 1 R9 Open Access Research Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery David M Shaw Ainsley M Sutherland James A Russell Samuel V Lichtenstein and Keith R Walley Critical Care Research Laboratories Heart Lung Institute University of British Columbia 1081 Burrard Street Vancouver BC V6Z 1Y6 Canada Corresponding author Keith R Walley kwalley@ Received 3 Sep 2008 Revisions requested 28 Oct 2008 Revisions received 1 Dec 2008 Accepted 29 Jan 2009 Published 29 Jan 2009 Critical Care 2009 13 R9 doi cc7698 This article is online at http content 13 1 R9 2009 Shaw et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Interleukin IL -18 is a key modulator of the cytokine response that leads to organ dysfunction and prolonged intensive care unit ICU stay after cardiopulmonary bypass surgery. We hypothesised that variation in the pro-inflammatory gene IL-18 is associated with adverse clinical outcome because of a more intense inflammatory response. Methods Haplotypes of the IL-18 gene were inferred from genotypes of 23 Coriell Registry subjects. Four haplotype tag single nucleotide polymorphisms -607 C A -137 G C 8148 C T and 9545 T G identified four major haplotype clades. These polymorphisms were genotyped in 658 Caucasian patients undergoing cardiopulmonary bypass surgery. Clinical phenotypes were collected by retrospective chart review. Results Patients homozygous for the T allele of the 9545 T G polymorphism had an increased occurrence of prolonged ICU stay for TT genotype versus for GG or GT genotype p . Patients homozygous for the T allele also had increased occurrence

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