TAILIEUCHUNG - Báo cáo y học: " The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription. | Retrovirology BioMed Central Short report Open Access The integrase interactor I INI1 proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription Yasuo Ariumi1 2 Fatima Serhan1 4 Priscilla Turelli1 4 Amalio Telenti3 and Didier Trono 1 4 Address Department of Microbiology and Molecular Medicine University of Geneva and Frontiers in Genetics National Center for Competence in Research Switzerland 2Department of Molecular Biology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan 3Institute of Microbiology CHUV University of Lausanne Lausanne Switzerland and 4School of Life Sciences Ecole Polytechnique Fédérale de Lausanne EPFL Lausanne Switzerland Email Yasuo Ariumi - ariumi@ Fatima Serhan - Priscilla Turelli - Amalio Telenti - Didier Trono - Corresponding author Published 05 August 2006 Received 03 June 2006 Accepted 05 August 2006 Retrovirology 2006 3 47 doi 186 1742-4690-3-47 This article is available from http content 3 1 47 2006 Ariumi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Integration of human immunodeficiency virus type 1 HIV-1 into the host genome is catalyzed by the viral integrase IN and preferentially occurs within transcriptionally active genes. During the early phase of HIV-1 infection the incoming viral preintegration complex PIC recruits the integrase interactor 1 INI1 hSNF5 a chromatin remodeling factor which directly binds to HIV-1 IN. The impact of this event on viral replication is so far unknown although it has been hypothesized that it could tether the preintegration complex to

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