TAILIEUCHUNG - Báo cáo hóa học: " Hacking into bacterial biofilms: a new therapeutic challenge"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Hacking into bacterial biofilms: a new therapeutic challenge | Bordi and de Bentzmann Annals of Intensive Care 2011 1 19 http content 1 1 19 Ù Annals of Intensive Care a SpringerOpen Journal REVIEW Open Access Hacking into bacterial biofilms a new therapeutic challenge Christophe Bordi and Sophie de Bentzmann Abstract Microbiologists have extensively worked during the past decade on a particular phase of the bacterial cell cycle known as biofilm in which single-celled individuals gather together to form a sedentary but dynamic community within a complex structure displaying spatial and functional heterogeneity. In response to the perception of environmental signals by sensing systems appropriate responses are triggered leading to biofilm formation. This process involves various molecular systems that enable bacteria to identify appropriate surfaces on which to anchor themselves to stick to those surfaces and to each other to construct multicellular communities several hundreds of micrometers thick and to detach from the community. The biofilm microbial community is a unique highly competitive and crowded environment facilitating microevolutionary processes and horizontal gene transfer between distantly related microorganisms. It is governed by social rules based on the production and use of public goods with actors and recipients. Biofilms constitute a unique shield against external aggressions including drug treatment and immune reactions. Biofilm-associated infections in humans have therefore generated major problems for the diagnosis and treatment of diseases. Improvements in our understanding of biofilms have led to innovative research designed to interfere with this process. Review Inside biofilms Biofilm notion is based on single-celled unicellular individuals bacteria fungi or yeasts forming a sedentary community within a complex structure displaying spatial and functional heterogeneity 1 . Bacterial biofilms account for a particular problem for human health because they are responsible for

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