TAILIEUCHUNG - Báo cáo y học: "The utility of the mannitol challenge in the assessment of chronic cough: a pilot study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The utility of the mannitol challenge in the assessment of chronic cough: a pilot study. | Cough BioMed Central Open Access Short report The utility of the mannitol challenge in the assessment of chronic cough a pilot study Amisha Singapuri Susan McKenna and Christopher E Brightling Address Institute of Lung Health University of Leicester Glenfield Hospital Groby Road Leicester LE3 9QP UK Email Amisha Singapuri - a_singapuri@ Susan McKenna - Christopher E Brightling - ceb17@ Corresponding author Published 18 November 2008 Received 25 September 2008 Cough 2008 4 10 doi 186 1745-9974-4-10 Accepted 18 November 2008 This article is available from http content 4 1 10 2008 Singapuri et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ There is a need for more objective outcome measures for chronic cough. In this pilot study we sought to investigate the utility of the mannitol challenge as a cough-provocation test in nonasthmatic chronic cough. We studied 16 healthy controls and 13 subjects with chronic cough. We assessed cough severity using a visual analogue score capsaicin cough sensitivity health status using the Leicester Cough Questionnaire and the dose of mannitol to cause 2 C2 or 5 C5 coughs. In all of the subjects with chronic cough and 6 of the controls we assessed the 1-week repeatability of the mannitol challenge. We found that in those subjects with chronic cough the geometric mean logSEM mannitol C2 and C5 was heightened compared to controls C2 4 versus 16 p and C5 63 versus 251 p . Cough visual analogue score capsacin-induced cough sensitivity and health status were also altered in chronic cough compared to healthy controls

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