TAILIEUCHUNG - Báo cáo y học: "CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolates"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolates. | Retrovirology BioMed Central Research Open Access CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolates Anna Laurén 1 Elzbieta Vincic1 Hiroo Hoshino2 Rigmor Thorstensson3 and Eva Maria Fenyo1 Address Department of Laboratory Medicine Division of Medical Microbiology Virology Lund University Lund Sweden 2Department of Virology and Preventive Medicine Gunma University Graduate School of Medicine Gunma Japan and 3Swedish Institute for Infectious Disease Control Stockholm Sweden Email Anna Laurén - Elzbieta Vincic - Hiroo Hoshino - Hoshino@ Rigmor Thorstensson - Eva Maria Fenyo - Corresponding author Published 23 July 2007 Received 22 March 2007 Retrovirology 2007 4 50 doi l742-4690-4-50 Accepted 23 July 2007 This article is available from http content 4 1 50 2007 Laurén et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background CD4-independence has been taken as a sign of a more open envelope structure that is more accessible to neutralizing antibodies and may confer altered cell tropism. In the present study we analyzed SIVsm isolates for CD4-independent use of CCR5 mode of CCR5-use and macrophage tropism. The isolates have been collected sequentially from 13 experimentally infected cynomolgus macaques and have previously been shown to use CCR5 together with CD4. Furthermore viruses obtained early after infection were neutralization sensitive while neutralization resistance appeared already three months after infection in monkeys with progressive immunodeficiency. Results Depending whether isolated early or late in infection two phenotypes

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