TAILIEUCHUNG - Báo cáo y học: " Peptide P5 (residues 628–683), comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site, is a potent inhibitor of HIV-1 infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Peptide P5 (residues 628–683), comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site, is a potent inhibitor of HIV-1 infection. | Retrovirology BioMed Central Research Peptide P5 residues 628-683 comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site is a potent inhibitor of HIV-1 infection Huifeng Yu1 2 Daniela Tudor1 2 Annette Alfsen1 2 Beatrice Labrosse3 4 Francois Clavel3 4 and Morgane Bomsel 1 2 Address 1Entrée Muqueuse du VIH et Immunité Muqueuse Mucosal Entry of HIV-1 and Mucosal Immunity Departement de Biologie Cellulaire Cell Biology Department Institut Cochin Université Paris Descartes CNRS UMR 8104 22 rue Mechain 75014 Paris France 2Inserm U567 Paris France 3Inserm U552 Hopital Bichat-Claude Bernard 46 rue Henri Huchard 75018 Paris France and 4Université Paris Diderot Paris France Email Huifeng Yu - yu@ DanielaTudor - Annette Alfsen - Beatrice Labrosse - Francois Clavel - Morgane Bomsel - Corresponding author Open Access Published 16 October 2008 Received 9 July 2008 Retrovirology 2008 5 93 doi 1742-4690-5-93 Accepted 16 October 2008 This article is available from http content 5 1 93 2008 Yu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The membrane proximal region MPR of the transmembrane subunit gp41 of the HIV envelope glycoprotein plays a critical role in HIV-1 infection of CD4 target cells and CD4-independent mucosal entry. It contains continuous epitopes recognized by neutralizing IgG antibodies 2F5 4E10 and Z13 and is therefore considered to be a promising target for vaccine design. Moreover some MPR-derived peptides such as T20 enfuvirtide are in clinical use as HIV-1 inhibitors. We have shown .

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