TAILIEUCHUNG - Micronuclei in neonates and children: effects of environmental, genetic, demographic and disease variables

The period of camping (March and May) being a rainy season, coupled with the location of the camp, poor sanitation and drainage system could all encourage the breeding of mosquitoes (the malaria vector). The diarrhoea prevalence rate of is equally higher than the value reported for the normal population of Nigeria (being 28%) (UNICEF, 2005). Diarrhoea is a major killer of children per annum the poor sanitary condition and unsafe water sources may be responsible for the observed higher prevalence of Diarrhoeas. This justified the oral Dehydration intervention programme that was being run by the. | Mutagenesis vol. 26 no. 1 pp. 51-56 2011 doi mutage geq064 REVIEW Micronuclei in neonates and children effects of environmental genetic demographic and disease variables Nina Holland Alexandra Fucic1 Domenico Franco Merlo2 Radim Sram3 and Micheline Kirsch-Volders4 School of Public Health 733 University Hall University of California Berkeley CA 94720-7360 USA 1Institute for Medical Research and Occupational Health Zagreb Croatia 2Unit of Epidemiology Biostatistics and Clinical Trials Department of Cancer Epidemiology and Prevention National Cancer Research Institute Largo Roanna Benzi 10 16132 Genoa Italy 3Institute of Experimental Medicine Academy of Science of Czech Republic Videnska 1083 142 20 Prague 4 Czech Republic and 4Laboratory for Cell Genetics Vrije Universiteit Brussel Brussels Belgium To whom correspondence should be addressed. School of Public Health 733 University Hall University of California Berkeley CA 94720-7360 USA. Tel 510 665 2200 Fax 510 665 2202 Email ninah@ Received on June 1 2010 revised on August 9 2010 accepted on August 25 2010 Children may be more susceptible to the effects of the environmental exposure and medical treatments than adults however limited information is available about the differences in genotoxic effects in children by age sex and health status. Micronucleus MN assay is a well established method of monitoring genotoxicity and this approach is thoroughly validated for adult lymphocytes by the Human Micronucleus Biomonitoring project . Similar international undertaking is in progress for exfoliated buccal cells. Most of the MN studies in children are focused on analyses of lymphocytes but in the recent years more investigators are interested in using exfoliated cells from the oral cavity and other cell types that can be collected non-invasively which is particularly important in paediatric cohorts. The baseline MN frequency is relatively low in newborns and its assessment requires large cohorts

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