TAILIEUCHUNG - Coeliac Disease in Indian Children: Assessment of Clinical, Nutritional and Pathologic Characteristics

The World Health Organization, for example, first developed the Expanded Programme on Immunization and subsequently the Programme for the Control of Diarrhoeal Diseases. UNICEF chose four specific interventions on which to focus: growth monitoring, oral rehydration therapy, breast- feeding promotion, and immunization, known by the acronym GOBI. It later added three more (food, family planning, and female education). Bilateral donors followed, channelling funds into what came to be called ‘‘child survival’’ programmes; these retained their roots in community-oriented, popula- tion-based, primary health care, but at the same time had the appeal of using relatively inexpensivemedical technologies to reach specific, stated objectives. Although the two strategies, at different ends of the intervention spectrum, have been able to coexist. | J HEALTH POPUL NUTR 2001 Sep 19 3 204-208 2001 ICDDR B Centre for Health and Population Research ISSN 1606-0997 Coeliac Disease in Indian Children Assessment of Clinical Nutritional and Pathologic Characteristics S. Mohindra1 . Yachha1 A. Srivastava1 N. Krishnani2 R. Aggarwal1 . Ghoshal1 . Prasad2 and . Naik1 -Departments of Gastroenterology and Pathology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow UP 226014 India ABSTRACT Coeliac disease is an important cause of chronic diarrhoea failure to thrive and anaemia in children. Little information on the disease is available in India. This study was undertaken to determine the prevalence clinical anthropometric and histological profiles of coeliac disease in patients attending a tertiary referral centre in India. Coeliac disease was diagnosed in 42 of 246 children with chronic diarrhoea failure to thrive and anaemia. The mean ages at onset of symptoms and at diagnosis were range years and range 3-14 years respectively and a mean period of delay in diagnosis was range years. Of the 42 cases history of failure to thrive was observed in 38 90 chronic diarrhoea in 37 88 and anaemia in 6 cases. Short stature under-nutrition anaemia oedema of feet rickets clubbing of fingers features of vitamin A deficiency and B-vitamin deficiency were found in 42 26 38 9 8 6 3 and 2 cases respectively. Onset of symptoms such as chronic diarrhoea and failure to thrive was earlier in children with subtotal villous atrophy than in those with partial villous atrophy mean SD years vs years p . Results of the study suggest that coeliac disease is not uncommon in Indian children. Coeliac disease should be considered in the differential diagnosis particularly in children without any symptoms of diarrhoea. Key words Coeliac disease Diarrhoea Diarrhoea Infantile Anaemia Infant growth Child growth India INTRODUCTION Coeliac disease is an enteropathy .

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