TAILIEUCHUNG - báo cáo khoa học: " Functional genomics and rheumatoid arthritis: where have we been and where should we go?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Functional genomics and rheumatoid arthritis: where have we been and where should we go? | Jarvis and Frank Genome Medicine 2010 2 44 http content 2 7 44 w Genome Medicine REVIEW L_ Functional genomics and rheumatoid arthritis where have we been and where should we go James N Jarvis1 and Mark Barton Frank2 Abstract Studies in model organisms and humans have begun to reveal the complexity of the transcriptome. In addition to serving as passive templates from which genes are translated RNA molecules are active functional elements of the cell whose products can detect interact with and modify other transcripts. Gene expression profiling is the method most commonly used thus far to enrich our understanding of the molecular basis of rheumatoid arthritis in adults and juvenile idiopathic arthritis in children. The feasibility of this approach for patient classification for example active versus inactive disease disease subsets and improving prognosis for example response to therapy has been demonstrated over the past 7 years. Mechanistic understanding of disease-related differences in gene expression must be interpreted in the context of interactions with transcriptional regulatory molecules and epigenetic alterations of the genome. Ongoing work regarding such functional complexities in the human genome will likely bring both insight and surprise to our understanding of rheumatoid arthritis. Rheumatoid arthritis as a complex trait Rheumatoid arthritis RA is a condition characterized by chronic inflammation and proliferation of synovial membranes. The disease has a worldwide distribution although it appears to show higher prevalence rates in specific populations for example indigenous Americans 1 . A strong genetic component is suspected based on twin studies studies of specific gene loci such as the human leukocyte antigen HLA locus and more recently gene linkage and genome-wide association Correspondence James-jarvis@ department of Pediatrics Pediatric Rheumatology Research Basic Science Education Building 235A University of

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